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| Thai / English name |
Part Used : กิ่งActivity : DRUG INTERACTIONSolvent/Active Compound : ethanolType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 0.4 g/kgDuration : -Type of interaction : PharmacokineticsInteraction with drug : Paclitaxel*/Taxol/PTXDose/Conc.(drug) : 10 mg/kg (intragastric), 30 mg/kg (intragastric), 1 mg/kg (intravenous)Result : PositiveRemark : The results showed that the AUC and Cmax of paclitaxel in rats receiving the T. yunnanensis extract were significantly increased than those receiving the pure paclitaxel, and the in vitro Caco-2 cell monolayer transport study found that the coexisting constituents in the extract of T. yunnanensis could inhibit the efflux of paclitaxel. These findings suggested that the oral absorption and bioavailability of paclitaxel in T. yunnanensis extract were remarkably higher when compared with the pure paclitaxel, and the coexisting constituents in the T. yunnanensis extract might play an important role for the enhancement of the oral absorption and bioavailability of paclitaxel.Note : Twenty-five rats were randomly divided into five groups: Group I, paclitaxel (i.g., 10 mg/kg); Group II, T. yunnanensis extract (i.g., 0.4 g/kg, equivalent to 10 mg/kg paclitaxel); Group III, paclitaxel (i.g., 30 mg/kg); Group IV, T. yunnanensis extract (i.g., 1.2 g/kg, equivalent to 30 mg/kg paclitaxel); and Group V, paclitaxel (i.v., 1 mg/kg).
Part Used : กิ่งActivity : DRUG INTERACTIONSolvent/Active Compound : ethanolType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1.2 g/kgDuration : -Type of interaction : PharmacokineticsInteraction with drug : Paclitaxel*/Taxol/PTXDose/Conc.(drug) : 10 mg/kg (intragastric), 30 mg/kg (intragastric), 1 mg/kg (intravenous)Result : PositiveRemark : The results showed that the AUC and Cmax of paclitaxel in rats receiving the T. yunnanensis extract were significantly increased than those receiving the pure paclitaxel, and the in vitro Caco-2 cell monolayer transport study found that the coexisting constituents in the extract of T. yunnanensis could inhibit the efflux of paclitaxel. These findings suggested that the oral absorption and bioavailability of paclitaxel in T. yunnanensis extract were remarkably higher when compared with the pure paclitaxel, and the coexisting constituents in the T. yunnanensis extract might play an important role for the enhancement of the oral absorption and bioavailability of paclitaxel.Note : Twenty-five rats were randomly divided into five groups: Group I, paclitaxel (i.g., 10 mg/kg); Group II, T. yunnanensis extract (i.g., 0.4 g/kg, equivalent to 10 mg/kg paclitaxel); Group III, paclitaxel (i.g., 30 mg/kg); Group IV, T. yunnanensis extract (i.g., 1.2 g/kg, equivalent to 30 mg/kg paclitaxel); and Group V, paclitaxel (i.v., 1 mg/kg).
