Synonym |
Thai / English name |
Part Used : ไม่ระบุActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : DecursinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 microgram/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : AstemizoleDose/Conc.(drug) : 1 micromolarResult : PositiveRemark : Decursin inhibited the CYP2J2 catalyzed astemizole with 66% inhibition.
Part Used : ไม่ระบุActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : DecursinolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 microgram/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : AstemizoleDose/Conc.(drug) : 1 micromolarResult : PositiveRemark : Decursinol inhibited the CYP2J2 catalyzed astemizole with 27% inhibition.
Part Used : ไม่ระบุActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : NodakeninType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 microgram/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : AstemizoleDose/Conc.(drug) : 1 micromolarResult : NegativeRemark : Nodakenin B could not inhibit the CYP2J2 catalyzed astemizole.
Part Used : ไม่ระบุActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : Praeruptorin AType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 microgram/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : AstemizoleDose/Conc.(drug) : 1 micromolarResult : NegativeRemark : Praeruptorin A could not inhibit the CYP2J2 catalyzed astemizole.
Part Used : ไม่ระบุActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : DecursinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 microgram/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : AstemizoleDose/Conc.(drug) : 1 micromolarResult : PositiveRemark : Decursin also inhibited CYP2J2 catalyzed astemizole O-demethylation and terfenadine hydroxylation activity with IC50 value of 10.18 and 1.8 micromolar, respectively, in recombinant CYP2J2 isoform.