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Part Used : ทั้งต้นActivity : CYP2C9 INDUCTIONSolvent/Active Compound : aqueous extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 0.58 g/kg, twice dailyDuration : 7 daysType of interaction : PharmacokineticsInteraction with drug : TolbutamideDose/Conc.(drug) : -Result : PositiveRemark : Polygonum capitatum pre-treatment had no significant effect on the pharmacokinetic parameters of caffeine, omeprazole or chlorzoxazone. However, the pharmacokinetics of tolbutamide and midazolam were affected significantly (P<0.05) by Polygonum capitatum, which induced more rapid metabolism of these probe compounds. These results suggested that Polygonum capitatum could induce CYP2C9 and CYP3A4, and did not influence CYP1A2, CYP2C19 or CYP2E1.
Part Used : ทั้งต้นActivity : CYP2C9 INDUCTIONSolvent/Active Compound : aqueous extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 0.58 g/kg, twice dailyDuration : 14 daysType of interaction : PharmacokineticsInteraction with drug : TolbutamideDose/Conc.(drug) : -Result : PositiveRemark : Polygonum capitatum pre-treatment had no significant effect on the pharmacokinetic parameters of caffeine, omeprazole or chlorzoxazone. However, the pharmacokinetics of tolbutamide and midazolam were affected significantly (P<0.05) by Polygonum capitatum, which induced more rapid metabolism of these probe compounds. These results suggested that Polygonum capitatum could induce CYP2C9 and CYP3A4, and did not influence CYP1A2, CYP2C19 or CYP2E1.
Part Used : ทั้งต้นActivity : CYP2C9 INDUCTIONSolvent/Active Compound : aqueous extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1.74 g/kg, twice dailyDuration : 7 daysType of interaction : PharmacokineticsInteraction with drug : TolbutamideDose/Conc.(drug) : -Result : PositiveRemark : Polygonum capitatum pre-treatment had no significant effect on the pharmacokinetic parameters of caffeine, omeprazole or chlorzoxazone. However, the pharmacokinetics of tolbutamide and midazolam were affected significantly (P<0.05) by Polygonum capitatum, which induced more rapid metabolism of these probe compounds. These results suggested that Polygonum capitatum could induce CYP2C9 and CYP3A4, and did not influence CYP1A2, CYP2C19 or CYP2E1.
Part Used : ทั้งต้นActivity : CYP2C9 INDUCTIONSolvent/Active Compound : aqueous extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1.74 g/kg, twice dailyDuration : 14 daysType of interaction : PharmacokineticsInteraction with drug : TolbutamideDose/Conc.(drug) : -Result : PositiveRemark : Polygonum capitatum pre-treatment had no significant effect on the pharmacokinetic parameters of caffeine, omeprazole or chlorzoxazone. However, the pharmacokinetics of tolbutamide and midazolam were affected significantly (P<0.05) by Polygonum capitatum, which induced more rapid metabolism of these probe compounds. These results suggested that Polygonum capitatum could induce CYP2C9 and CYP3A4, and did not influence CYP1A2, CYP2C19 or CYP2E1.
