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Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : 60% ethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Herbal solution (100 microlitre, seven different concentrations for each herb ranging from 4 to 28000 microgram/ml in 4% ethanol)Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The IC50 constants of black elderberry extract for CYP1A2, CYP2D6, and CYP3A4 inhibition were 3612+/-210, 4323+/-356, and 3086+/-120 microgram/ml, respectively.
Part Used : ดอกActivity : DRUG INTERACTIONSolvent/Active Compound : dimethyl sulfoxide (DMSO): methanol (1:1, v/v)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Elderberry extract >500 microgram/mLDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark :Note : Five berries (bilberry, blueberry, cranberry, elderberry, and raspberry ketones) are unlikely to cause clinically significant herb-drug interactions mediated via inhibition of UGT enzymes involved in drug metabolism.
