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| Thai / English name |
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 15N(Treatment) : -Sex : Both sexAge : 78+-/6 yrs.Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : Aspirin*/Acetylsalicylic acid/ASA/EcosprinDose/Conc.(drug) : -Result : PositiveRemark : Result: Ginseng + Aspirin = Increased risk of bleeding (No. Potential or Possible Interactions = 1 of 45)Note : Subject total: Subjects were veterans over the age of 65 years who are frail and have complex medical and psychosocial problems.
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : Asian or Siberian ginsengType of experiment : humanType of animal : -Type of study : Open trialN(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : DigoxinDose/Conc.(drug) : -Result : NegativeRemark : Result: Serum pools prepared from samples from patients receiving digoxin and then supplemented with Asian or Siberian ginseng showed falsely increased digoxin values using the fluorescence polarization immunoassay (FPIA) falsely decreased values using the microparticle enzyme immunoassay (MEIA). Digoxin-like immunoreactive substances (DLISs) showed synergistic effects with ginsengs in interfering with the FPIA and MEIA for digoxin. No interference was observed with 3 other digoxin assays, even in the presence of elevated DLISs.Note : Data incomplete.
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : DigoxinDose/Conc.(drug) : -Result : PositiveRemark : Result: When aliquots of a digoxin pool prepared from patients receiving digoxin were supplemented with these Chinese medicines, the most significant interference with the fluorescence polarization immunoassay (FPIA) was observed. The presence of endogenous digoxin-like immunoreactive substances can have additive effects with these Chinese medicines and falsely increase apparent digoxin levels by the FPIA. On the other hand, the Roche and Beckman assays were free from interference from DLIS but showed significant interference from Chan Su and Lu-Shen-Wan.Note : Data incomplete.
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12*N(Treatment) : 12Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) : -Duration : A single 25-mg dose of warfarin after 7 days' pretreatment with ginseng. Dosing with ginseng was continued for 7 days after administration of the warfarin doseType of interaction : P.Kinetics & P.DynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : NegativeRemark : Result: INR and platelet aggregation were not affected by treatment with ginseng. Ginseng did not affect the apparent vols. of distribution or protein binding of warfarin enantiomers. Coadministration of warfarin with ginseng did not affect the pharmacokinetics or pharmacodynamics of either S-warfarin or R-warfarin.Note : Type of study: open-label, three-way crossover randomized study. Subject total: Healthy volunteers. Data incomplete.
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 12*N(Treatment) : 12Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) : -Duration : A single 25-mg dose of warfarin after 7 days' pretreatment with ginseng. Dosing with ginseng was continued for 7 days after administration of the warfarin doseType of interaction : P.Kinetics & P.DynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : NegativeRemark : Result: INR and platelet aggregation were not affected by treatment with ginseng. Ginseng did not affect the apparent vols. of distribution or protein binding of warfarin enantiomers. Coadministration of warfarin with ginseng did not affect the pharmacokinetics or pharmacodynamics of either S-warfarin or R-warfarin.Note : Type of study: open-label, three-way crossover randomized study. Subject total: Healthy volunteers. Data incomplete.
