| Synonym |
| Thai / English name |
Part Used : ไม่ระบุActivity : CYP3A4 INHIBITIONSolvent/Active Compound : ginsenoside Rh1Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 10-100 micromolarsDuration : 10 min incubationType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: Rh1 exhibited competitive inhibition of the activity of CYP3A4 with Ki values of 57.7+/-9.6 micromolarNote : Type of experiment: Human livers were obtained from three Chinese autopsy sample (males, ages 27, 29 and 42 years). Conclusion: The degradation of ginsenosides in the gastrointestinal tract may play an important role in the ginseng-associated drug-drug interactions, but the effects might be not due to Rh1 and F1.
Part Used : ไม่ระบุActivity : CYP3A4 INHIBITIONSolvent/Active Compound : ginsenoside F1Type of experiment : -Type of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 10-100 micromolars of F1Duration : 10 min incubationType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: F1 exhibited competitive inhibition of the activity of CYP3A4 with Ki values of 67.8+/-16.2 micromolarNote : Type of experiment: Human livers were obtained from three Chinese autopsy sample (males, ages 27, 29 and 42 years). Conclusion: The degradation of ginsenosides in the gastrointestinal tract may play an important role in the ginseng-associated drug-drug interactions, but the effects might be not due to Rh1 and F1.
Part Used : ไม่ระบุActivity : CYP3A4 INHIBITIONSolvent/Active Compound : ginsenosides F1Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : ginsenosides F1 10 mMDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: Many of the exts./constituents exerted >/=50% inhibition of P 450 activity. Ginsenosides F1 and Rh1 (but not ginseng ext.) inhibiting CYP3A4 at 10 mM.Note : Result: The data suggest that the clearance of a variety of drugs may be diminished by concomitant use of these herbs via inhibition of P450 enzymes, but less so by Pgp-mediated effects. Data incomplete.
Part Used : ไม่ระบุActivity : CYP3A4 INHIBITIONSolvent/Active Compound : ginsenosides Rh1Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : ginsenosides Rh1 10 mMDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: Many of the exts./constituents exerted >/=50% inhibition of P 450 activity. Ginsenosides F1 and Rh1 (but not ginseng ext.) inhibiting CYP3A4 at 10 mM.Note : Result: The data suggest that the clearance of a variety of drugs may be diminished by concomitant use of these herbs via inhibition of P450 enzymes, but less so by Pgp-mediated effects. Data incomplete.
Part Used : -Activity : CYP3A4 INHIBITIONSolvent/Active Compound : methanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : EquivocalRemark : Type of experiment: human liver microsomes Results: Nine ginseng products studied had little to no effect on the activity of CYP3A4.Note : Data incomplete
