ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ไม่ระบุ

Activity : CYP3A INHIBITION

Solvent/Active Compound : ginsenosides

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : The concentrations of 20(S)-protopanaxadiol derivatives Rb1, Rb2, Rc, C-K and 20(S)-protopanaxatriol derivatives Re, Rg1, Rg2, Pt and Ppt were 500 micromolars, 500 micromolars, 250 micromolars, 500 micromolars, 500 micromolars, 500 micromolars, 100 micromolars, 500 micromolars, and 500 micromolars

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : -

Dose/Conc.(drug) : -

Result : Positive

Remark : Result: Ginsenosides from the 20(S)-protopanaxadiol and 20(S)-protopanaxatriol family including Rb1, Rb2, Rc, compound-K, Re, and Rg1 had no inhibitory effect, whereas Rg2, 20(S)-panaxatriol and 20(S)-protopanaxatriol exhibited competitive inhibitory activity against CYP3A activity in these microsomes with the inhibition constants (Ki) of 86.4+/-0.8 micromolars, 1.7 +/-0.1 micromolars, and 3.2 +/-0.2 micromolars, respectively.

Note : Type of experiment: rat liver microsomes

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