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Part Used : ไม่ระบุ

Activity : CYP2E1 INDUCTION

Solvent/Active Compound : ginsenoside Rh1

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : NS

N(Treatment) : NS

Sex : Male

Age : 27, 29, and 42 yrs.

Route : -

Dose/Conc.(herb) : 10-100 micromolar of Rb1

Duration : 10 min incubation

Type of interaction : Pharmacokinetics

Interaction with drug : -

Dose/Conc.(drug) : -

Result : Positive

Remark : Result: Rh1 exhibited a weak stimulation rather than an inhibition of the activity of CYP2E1.

Note : Type of experiment: Human livers were obtained from three Chinese autopsy sample (males, ages 27, 29 and 42 years). Conclusion: The degradation of ginsenosides in the gastrointestinal tract may play an important role in the ginseng-associated drug-drug interactions, but the effects might be not due to Rh1 and F1.

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