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| Thai / English name |
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12*N(Treatment) : 12Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) : -Duration : A single 25-mg dose of warfarin after 7 days' pretreatment with ginseng. Dosing with ginseng was continued for 7 days after administration of the warfarin doseType of interaction : P.Kinetics & P.DynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : NegativeRemark : Result: INR and platelet aggregation were not affected by treatment with ginseng. Ginseng did not affect the apparent vols. of distribution or protein binding of warfarin enantiomers. Coadministration of warfarin with ginseng did not affect the pharmacokinetics or pharmacodynamics of either S-warfarin or R-warfarin.Note : Type of study: open-label, three-way crossover randomized study. Subject total: Healthy volunteers. Data incomplete.
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 12*N(Treatment) : 12Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) : -Duration : A single 25-mg dose of warfarin after 7 days' pretreatment with ginseng. Dosing with ginseng was continued for 7 days after administration of the warfarin doseType of interaction : P.Kinetics & P.DynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : NegativeRemark : Result: INR and platelet aggregation were not affected by treatment with ginseng. Ginseng did not affect the apparent vols. of distribution or protein binding of warfarin enantiomers. Coadministration of warfarin with ginseng did not affect the pharmacokinetics or pharmacodynamics of either S-warfarin or R-warfarin.Note : Type of study: open-label, three-way crossover randomized study. Subject total: Healthy volunteers. Data incomplete.
