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Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : TamarixetinType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 9.32 mg/kgDuration : -Type of interaction : PharmacokineticsInteraction with drug : FluvastatinDose/Conc.(drug) : 1.5 mg/kgResult : PositiveRemark : Tamarixetin significantly increased the bioavailability of fluvastatin as demonstrated by a 2.2-fold increase in its peak concentration (Cmax) and a 2.4-fold increase in the area under the plasma concentration-time curve (AUCinf) whereas there was no apparent difference in the elimination half-life (T1/2) of fluvastatin between groups. Oral tamarixetin reduced fluvastatin metabolism by about 50% in vivo in the drug absorption phase but did not affect its distribution and disposition.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : TamarixetinType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 9.32 mg/kgDuration : -Type of interaction : PharmacokineticsInteraction with drug : FluvastatinDose/Conc.(drug) : 1.5 mg/kgResult : PositiveRemark : Tamarixetin significantly increased the bioavailability of fluvastatin as demonstrated by a 2.2-fold increase in its peak concentration (Cmax) and a 2.4-fold increase in the area under the plasma concentration-time curve (AUCinf) whereas there was no apparent difference in the elimination half-life (T1/2) of fluvastatin between groups. Oral tamarixetin reduced fluvastatin metabolism by about 50% in vivo in the drug absorption phase but did not affect its distribution and disposition.
