ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : หัว

Activity : P-GLYCOPROTEIN INHIBITION

Solvent/Active Compound : Methanol, chloroform, ethyl-acetate and aqueous extract

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : Plant extract 20 microgram/mL

Duration : The cells were incubated for 20 min at 37 degrees celsius

Type of interaction : Pharmacokinetics

Interaction with drug : -

Dose/Conc.(drug) : -

Result : Positive

Remark : Result: Fluorescence activity ratios (FAR) of methanol, chloroform, ethyl-acetate, and aqueous extracts of Asparagus cochinchinensis on mdr1 gene-transfected mouse lymphoma cell line = 1.09, 1.78, 0.94 and 0.86 microgram/mL, respectively (The FAR of the reference compound verapamil was 10.87: at 10 microgram/mL)

Note : They evaluated the P-gp-modulating effects of the Chinese herbal extracts and herbs on a mouse T-lymphoma cell line transfected with the human mdr1 cell line. The most effective resistance modifiers were found in MeOH extracts of Ligustrum lucidum, and Atractylodes macrocephala; Aconitum carmichaeli (Debx.) was ineffective. The most effective CHCl3 extracts were: Ligustrum lucidum, Aconitum carmichaeli, Atractylodes marcrocephala and Asarum heteropoides. The MDR-reversing activity of EtOAc extracts Aconitum carmichaeli and Atractylodes macrocephala were noteworthy. H2O extract of Asarum heteropoides was effective inhibitor of MDR, whereas Asparagus cochinchinensis, Ligustrum lucidum, Aconitum carmichaeli and Atractylodes macrocephala were ineffective. Of the four types of extracts studied, CHCl3 extracts demonstrated the highest P-gp-inhibitory effects on mouse lymphoma cells, blocking the function of P-gp.

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