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Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Single-blind trialN(Total) : 13N(Treatment) : 13Sex : MaleAge : 35 +/- 8 yrs.Route : Oral administrationDose/Conc.(herb) : 8 ozDuration :Type of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : 6 mg (p.o.)Result : PositiveRemark : Subjects: healthy male volunteers participated in a randomized, single-dose, 5-way crossover study, with 1 week elapsing between trials. The 5 treatment groups were: 1. Intravenous (IV) midazolam (2 mg) preceded by water 2. Oral midazolam (6 mg) preceded by water 3. IV midazolam (2 mg) preceded by pomegranate juice 4. Oral midazolam (6 mg) preceded by pomegranate juice 5. Oral midazolam (6 mg) preceded by grapefruit juice Results: Pretreatment of volunteer subjects with pomegranate juice did not alter the elimination half-life, volume of distribution, or clearance of intravenous midazolam (2 mg). Administration of pomegranate juice also did not affect Cmax, total area under the curve (AUC), or clearance of oral midazolam (6 mg).
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 13N(Treatment) : 13Sex : MaleAge : 35 +/- 8 yrs.Route : Oral administrationDose/Conc.(herb) : 8 ozDuration :Type of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : 6 mg (p.o.)Result : PositiveRemark : Subjects: healthy male volunteers participated in a randomized, single-dose, 5-way crossover study, with 1 week elapsing between trials. The 5 treatment groups were: 1. Intravenous (IV) midazolam (2 mg) preceded by water 2. Oral midazolam (6 mg) preceded by water 3. IV midazolam (2 mg) preceded by pomegranate juice 4. Oral midazolam (6 mg) preceded by pomegranate juice 5. Oral midazolam (6 mg) preceded by grapefruit juice Results: Pretreatment of volunteer subjects with pomegranate juice did not alter the elimination half-life, volume of distribution, or clearance of intravenous midazolam (2 mg). Administration of pomegranate juice also did not affect Cmax, total area under the curve (AUC), or clearance of oral midazolam (6 mg).
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 microgram/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark :
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mL/kg for grapefruit juiceDuration : Single administrationType of interaction : PharmacokineticsInteraction with drug : TacrolimusDose/Conc.(drug) : -Result : PositiveRemark : The AUC values of tacrolimus in the rat pre-treated with grapefruit juice, ginger juice, and turmeric juice were significantly larger than those pre-treated with water. These AUC values were almost equal to the values for those pre-treated with 100% pomelo juice.
Part Used : ผลActivity : DRUG INTERACTIONSolvent/Active Compound : hidroalcoholic / 10% synephrineType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 164 mg/kgDuration : a single doseType of interaction : PharmacokineticsInteraction with drug : AmiodaroneDose/Conc.(drug) : 50 mg/kgResult : PositiveRemark : - It deserves to be highlighted the significant increase of the peak plasma concentration of amiodarone in rats pre-treated with C. aurantium extract, while the extent of systemic exposure was comparable between both groups.Note : - This paper reports, data on the potential of herb-drug interaction between C. aurantium extract and amiodarone.
Part Used : ผลActivity : DRUG INTERACTIONSolvent/Active Compound : hidroalcoholic / 10% synephrineType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 164 mg/kgDuration : 14 dayType of interaction : PharmacokineticsInteraction with drug : AmiodaroneDose/Conc.(drug) : 50 mg/kg on the 15th dayResult : PositiveRemark : - It deserves to be highlighted the significant increase of the peak plasma concentration of amiodarone in rats pre-treated with C. aurantium extract, while the extent of systemic exposure was comparable between both groups.Note : - This paper reports, data on the potential of herb-drug interaction between C. aurantium extract and amiodarone.
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : grapefruit juice (GFJ)Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 7N(Treatment) : 7Sex : MaleAge : 21-24 yrs.Route : Oral administrationDose/Conc.(herb) : *Duration : 7 daysType of interaction : PharmacokineticsInteraction with drug : CeliprololDose/Conc.(drug) : -Result : PositiveRemark : *Dose: They were orally administered celiprolol (100 mg) with water on the control day. Three days later, they ingested GFJ (200 mL) 3 times a day for 3 d. On day 1, the same drugs were administered with GFJ. On days 3 and 7, the same drugs were administered with water. Pharmacokinetics of drug was evaluated on each trial day. Result: The peak plasma concentration (Cmax) and the area under the plasma concentration-time curve from 0 to 8 h (AUC0-8) of celiprolol significantly decreased on day 1, and the mean ratios of these values and the corresponding control-day values were 0.18 and 0.25, respectively. The Cmax and AUC0-8 returned to the control levels on days 3 and 7.Note : Conclusion: The OATP inhibition caused by GFJ dissipated faster than GFJ- mediated alterations in CYP3A4 activity, which were sustained for at least 48 h. Celiprolol and midazolam are substrated of OATP and CYP3A4.
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : grapefruit juice (GFJ)Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 7N(Treatment) : 7Sex : MaleAge : 21-24 yrs.Route : Oral administrationDose/Conc.(herb) : *Duration : 7 daysType of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : -Result : PositiveRemark : *Dose: They were orally administered celiprolol (100 mg) with water on the control day. Three days later, they ingested GFJ (200 mL) 3 times a day for 3 d. On day 1, the same drugs were administered with GFJ. On days 3 and 7, the same drugs were administered with water. Pharmacokinetics of drug was evaluated on each trial day. Result: (AUC0-8) of midazolam was higher on days 1 and 3 than on the control day (mean ratio, 2.12 and 1.47, respectively). The AUC0-8 returned to the control level on day 7.Note : Conclusion: The OATP inhibition caused by GFJ dissipated faster than GFJ- mediated alterations in CYP3A4 activity, which were sustained for at least 48 h. Celiprolol and midazolam are substrated of OATP and CYP3A4.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : rutinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.5-2.0 x10^5 mol/LDuration : -Type of interaction : PharmacokineticsInteraction with drug : NevirapineDose/Conc.(drug) :Result : PositiveRemark : The association constants of NDP binding to HSA decrease with increase of rutin concentration. When the [rutin]:[HSA] ratio is 2, it decreases by 38.65% compared with that without rutin. The binding distance between the amino acid residue of HSA and NDP is 2.608 nm and in the presence of rutin, it increases to 2.700 nm. The results indicated that the flavonoid binding in site I hinders the access of NDP to the interior of hydrophobic pocket of HSA, which induces the increase of binding distance between the amino acid residue of HSA and NDP.Note : HSA= human serum albumin NDP= nefedipine
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : grapefruit juice (GFJ)Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 21*N(Treatment) : 21Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) : 200 ml GFJDuration : For development of the pharmacokinetic model of felodipine-GFJ interaction in this study, they utilized pharmacokinetic data obtained from two clinical trials. In the first, nine healthy male volunteers were given 10 mg felodipine ER orally together with either 200 ml tap water or GFJ at 0, 1, 4, 10 or 24 h before administration of felodipine. In the second, 12 healthy male volunteers received 10 mg felodipine ER after daily intake of either 200 ml of tap water of GFJ for 1 day or 14 days.Type of interaction : PharmacokineticsInteraction with drug : FelodipineDose/Conc.(drug) : 10 mg felodipine ER (extended release formulation)Result : PositiveRemark : Result: The model gave a turnover rate of CYP3A4 of 0.0849 h-1, corresponding to a half-life of 8.16 h. Conclusions: GFJ-felodipine interaction increases with increasing frequency and amount of GFJ ingestion, and that an interval of 2-3 days between GFJ intake and felodipine administration is necessary if GFJ-felodipine interaction is to be avoided.
