Synonym |
Thai / English name |
Part Used : น้ำจากผลActivity : CYP3A5 INHIBITIONSolvent/Active Compound : Furanocoumarins, Fruit juices of pummel grapefruit (Citrus paradisi Macf)Type of experiment : in vitroType of animal : -Type of study : Open trialN(Total) : 12*N(Treatment) : 12Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) :Duration :Type of interaction : PharmacokineticsInteraction with drug : FelodipineDose/Conc.(drug) :Result : EquivocalRemark : Results: CYP3A5* polymorphism showed no significant effect on felodipine pharmacokinetics and related hemodynamic changes. This work supports the hypothesis that CYP3A inhibition by furanocoumarins caused pummelo fruit juice drug interaction; while the role of CYP3A5 in the population pharmacokinetics of felodipine and blood pressure response appear to be limited.Note : Data incomplete.
Part Used : น้ำจากผลActivity : CYP3A5 INHIBITIONSolvent/Active Compound : Furanocoumarins, Fruit juices of Changshanhuyou (Citrus changshanhuyou y.B. Chang)Type of experiment : in vitroType of animal : -Type of study : -N(Total) :N(Treatment) :Sex : -Age : -Route : -Dose/Conc.(herb) :Duration :Type of interaction : PharmacokineticsInteraction with drug : FelodipineDose/Conc.(drug) :Result : EquivocalRemark : Results: CYP3A5* polymorphism showed no significant effect on felodipine pharmacokinetics and related hemodynamic changes. This work supports the hypothesis that CYP3A inhibition by furanocoumarins caused pummelo fruit juice drug interaction; while the role of CYP3A5 in the population pharmacokinetics of felodipine and blood pressure response appear to be limited.Note : Data incomplete.