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Part Used : น้ำจากผลActivity : CYP1A2 INHIBITIONSolvent/Active Compound : bergamottinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 200 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) :Result : PositiveRemark : Results: lC50 values (micromolar) of test compounds for CYP1A2 inhibition = 0.48 micromolar lC50 values (micromolar) of test compounds for CYP2C9 inhibition = 0.33 micromolar lC50 values (micromolar) of test compounds for CYP2C19 inhibition = 0.19 micromolar lC50 values (micromolar) of test compounds for CYP2D6 inhibition = 0.35 micromolar lC50 values (micromolar) of test compounds for CYP3A4 (BFC) inhibition = 1.47 micromolarNote : Evaluated the effects of 25 purified components of commonly used herbal products on the catalytic activity of cDNA-expressed cytochrome P450 isoforms in in vitro experiments. Increasing concentrations of the compounds were incubated with a panel of recombinant human CYP isoforms (CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4) and their effects on the conversion of specific surrogate substrates measured fluorometrically in a 96-well plate format.
Part Used : น้ำจากผลActivity : CYP1A2 INHIBITIONSolvent/Active Compound : 6,7-dihydroxybergamottinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 217 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) :Result : PositiveRemark : Results: lC50 values (micromolar) of test compounds for CYP1A2 inhibition = 10.23 micromolar lC50 values (micromolar) of test compounds for CYP2C9 inhibition = 1.17 micromolar lC50 values (micromolar) of test compounds for CYP2C19 inhibition = 0.097 micromolar lC50 values (micromolar) of test compounds for CYP2D6 inhibition = 1.19 micromolar lC50 values (micromolar) of test compounds for CYP3A4 (BFC) inhibition = 1.66 micromolarNote : Evaluated the effects of 25 purified components of commonly used herbal products on the catalytic activity of cDNA-expressed cytochrome P450 isoforms in in vitro experiments. Increasing concentrations of the compounds were incubated with a panel of recombinant human CYP isoforms (CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4) and their effects on the conversion of specific surrogate substrates measured fluorometrically in a 96-well plate format.
Part Used : น้ำจากผลActivity : CYP1A2 INHIBITIONSolvent/Active Compound : naringeninType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 200 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) :Result : PositiveRemark : Results: lC50 values (micromolar) of test compounds for CYP1A2 inhibition = 83.09 micromolar lC50 values (micromolar) of test compounds for CYP2C9 inhibition = 2.57 micromolar lC50 values (micromolar) of test compounds for CYP2C19 inhibition = 3.48 micromolar lC50 values (micromolar) of test compounds for CYP2D6 inhibition = 159.12 micromolar lC50 values (micromolar) of test compounds for CYP3A4 (BzRes) inhibition = 11.90 micromolar lC50 values (micromolar) of test compounds for CYP3A4 (BFC) inhibition = 20.46 micromolarNote : Evaluated the effects of 25 purified components of commonly used herbal products on the catalytic activity of cDNA-expressed cytochrome P450 isoforms in in vitro experiments. Increasing concentrations of the compounds were incubated with a panel of recombinant human CYP isoforms (CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4) and their effects on the conversion of specific surrogate substrates measured fluorometrically in a 96-well plate format.
