ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : น้ำจากผล

Activity : CYP1A INHIBITION

Solvent/Active Compound : Dilute grapefruit juice

Type of experiment : human

Type of animal : -

Type of study : Cross over

N(Total) : 10* (M/F = 5/5)

N(Treatment) : 10 (M/F = 5/5)

Sex : Both sex

Age : 21 - 32 yrs.

Route : Oral administration

Dose/Conc.(herb) : a single oral of a felodipine 10-mg extended-release tablet with 240 mL of common orange juice (negative control)

Duration : Peripheral venous blood (7 mL) was collected just before felodipine and juice administration and at 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 12, and 24 hours thereafter

Type of interaction : Pharmacokinetics

Interaction with drug : Felodipine

Dose/Conc.(drug) : a single oral dose of felodipine 10-mg extended-release tablet

Result : Equivocal

Remark : Result: The common orange juice was used as negative control. *Subject toal: Subjects were healthy nonsmoking volunteers.

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