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RUTACEAE Citrus spp.

Synonym

none ...

Thai / English name

Citrus spp.

[1-6] of 6 article(s) found

หน้า 1

[1] POMEGRANATE JUICE DOES NOT IMPAIR CLEARANCE OF ORAL OR INTRAVENOUS MIDAZOLAM, A PROBE FOR CYTOCHROME P450-3A ACTIVITY: COMPARISON WITH GRAPEFRUIT JUICE.
FARKAS D,OLESON LE,ZHAO Y,ET AL.
J CLIN PHARMACOL 2007 Vol.47(3),286-94 $17053 [Full]

Part Used : น้ำจากผล
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 0.05-2.5% (v/v)

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: human liver microsomes Results: For grapefruit juice, the IC50 without preincubation was 0.55 (+/-0.03)%; after preincubation, this was significantly reduced to 0.41 (+/-0.03)%, indicating increased inhibitory potency.

[2] INHIBITION OF CYTOCHROME P450 3A4 ACTIVITY BY CRUDE EXTRACTS OF CITRUS JUICES.
SOTANAPHUN U,YAIPAKDEE P,CHAIWATPONGSAKORN S,ET AL.
THE 20th CONGRESS OF FEDERATION OF ASIAN PHARMACEUTICAL ASSOCIATIONS (FAPA), BANGKOK THAILAND, NOV. 30 - DEC 3, 2004 2004 Vol.(),238 275941 [Abstract]

Part Used : น้ำจากผล
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : Crude extract was prepared from squeezed juice of grapefruit

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Result: Grapefruit juice crude extract exhibited IC50 values of 76.96 +/- 12.28 microgram/mL

Note : Data incomplete

[3] RADICAL SCAVENGING AND CYTOCHROME P450 3A4 INHIBITORY ACTIVITY OF BERGAPTOL AND GERANYLCOUMARIN FROM GRAPEFRUIT.
GIRENNAVAR B,JAYAPRAKASHA GK,JADEGOUD Y,ET AL.
BIOORG MED CHEM 2007 Vol.15(11),3684-91 359617 [Abstract]

Part Used : น้ำจากผล
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : bergaptol

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Bergaptol was found to be potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 micromolar.

Note : Data incomplete

Part Used : เปลือกผล
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : bergaptol

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Bergaptol was found to be potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 micromolar.

Note : Data incomplete

Part Used : น้ำจากผล
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : geranylcoumarin

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Geranylcoumarin was found to be potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 42.93 micromolar.

Note : Data incomplete

Part Used : เปลือกผล
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : geranylcoumarin

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Geranylcoumarin was found to be potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 42.93 micromolar.

Note : Data incomplete

[4] DIFFERENT ROLES OF PUMMELO FURANOCOUMARIN AND CYTOCHROME P450 3A5*3 POLYMORPHISM IN THE FATE AND ACTION OF FELODIPINE.
GUO L-Q,CHEN Q-Y,WANG X,ET AL.
CURR DRUG METAB 2007 Vol.8(6),623-30 361757 [Abstract]

Part Used : น้ำจากผล
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : Furanocoumarins, Fruit juices of Changshanhuyou (Citrus changshanhuyou Y.B. Chang)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) :
N(Treatment) :

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) :

Duration :
Type of interaction : Pharmacokinetics

Interaction with drug : Felodipine
Dose/Conc.(drug) :

Result : Positive

Remark : Results: Citrus paradisi had more furanocoumarins and at higher levels than C. grandis Osbeck vs. Guanxi while C. changshanhuyou Y.B. Chang hand none, and their potencies for in vitro CYP3A inhibition were in the order as C. paradisi > C. grandis Osbeck vs. Guanxi > C. changshanhuyou Y.B. Chang.

Note : Data incomplete.

[5] INHIBITORY EFFECTS OF FRUIT JUICES ON CYP3A ACTIVITY.
KIM H,YOON Y-J,SHON J-H,ET AL.
DRUG METAB DISPOS 2006 Vol.34(4),521-3 373498 [Abstract]

Part Used : น้ำจากผล
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: human liver microsomes The inhibitory potential of human CYP3A was in the order: grapefruit > black mulberry > wild grape > pomegranate > black raspberry.

Note : Data incomplete

[6] POTENT INHIBITION BY STAR FRUIT OF HUMAN CYTOCHROME P450 3A (CYP3A) ACTIVITY.
HIDAKA M,FUJITA K,OGIKUBO T,ET AL.
DRUG METAB DISPOS 2004 Vol.32(6),581-3 373520 [Abstract]

Part Used : น้ำจากผล
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 0.2-6.0% (v/v)

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: human liver microsomes Among the tropical fruit juices tested (common papaw, dragon fruit, kiwi fruit, mango, passion fruit, pomegranate, rambutan, and star fruit), star fruit juice showed the most potent inhibition of CYP3A.

Note : Data incomplete

หน้า 1

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