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Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : rutinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.5-2.0 x10^5 mol/LDuration : -Type of interaction : PharmacokineticsInteraction with drug : NevirapineDose/Conc.(drug) :Result : PositiveRemark : The association constants of NDP binding to HSA decrease with increase of rutin concentration. When the [rutin]:[HSA] ratio is 2, it decreases by 38.65% compared with that without rutin. The binding distance between the amino acid residue of HSA and NDP is 2.608 nm and in the presence of rutin, it increases to 2.700 nm. The results indicated that the flavonoid binding in site I hinders the access of NDP to the interior of hydrophobic pocket of HSA, which induces the increase of binding distance between the amino acid residue of HSA and NDP.Note : HSA= human serum albumin NDP= nefedipine
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : rutinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.5-2.0 x10^5 mol/LDuration : -Type of interaction : PharmacokineticsInteraction with drug : NevirapineDose/Conc.(drug) :Result : PositiveRemark : The association constants of NDP binding to HSA decrease with increase of rutin concentration. When the [rutin]:[HSA] ratio is 2, it decreases by 38.65% compared with that without rutin. The binding distance between the amino acid residue of HSA and NDP is 2.608 nm and in the presence of rutin, it increases to 2.700 nm. The results indicated that the flavonoid binding in site I hinders the access of NDP to the interior of hydrophobic pocket of HSA, which induces the increase of binding distance between the amino acid residue of HSA and NDP.Note : HSA= human serum albumin NDP= nefedipine
Part Used : ไม่ระบุActivity : BINDING EFFECTSolvent/Active Compound : rutinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.5-2.0 x10^5 mol/LDuration : -Type of interaction : PharmacokineticsInteraction with drug : NevirapineDose/Conc.(drug) :Result : PositiveRemark : The association constants of NDP binding to HSA decrease with increase of rutin concentration. When the [rutin]:[HSA] ratio is 2, it decreases by 38.65% compared with that without rutin. The binding distance between the amino acid residue of HSA and NDP is 2.608 nm and in the presence of rutin, it increases to 2.700 nm. The results indicated that the flavonoid binding in site I hinders the access of NDP to the interior of hydrophobic pocket of HSA, which induces the increase of binding distance between the amino acid residue of HSA and NDP.Note : HSA= human serum albumin NDP= nefedipine
