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Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mL/kg for grapefruit juiceDuration : Single administrationType of interaction : PharmacokineticsInteraction with drug : TacrolimusDose/Conc.(drug) : -Result : PositiveRemark : The AUC values of tacrolimus in the rat pre-treated with grapefruit juice, ginger juice, and turmeric juice were significantly larger than those pre-treated with water. These AUC values were almost equal to the values for those pre-treated with 100% pomelo juice.
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mL/kg for grapefruit juiceDuration : Single administrationType of interaction : PharmacokineticsInteraction with drug : TacrolimusDose/Conc.(drug) : -Result : PositiveRemark : The AUC values of tacrolimus in the rat pre-treated with grapefruit juice, ginger juice, and turmeric juice were significantly larger than those pre-treated with water. These AUC values were almost equal to the values for those pre-treated with 100% pomelo juice.
Part Used : น้ำจากผลActivity : CYP3A4 INHIBITIONSolvent/Active Compound : grapefruit juice (GFJ)Type of experiment : in vitroType of animal : -Type of study : Cross-sectionN(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : TacrolimusDose/Conc.(drug) : -Result : PositiveRemark : Result: GFJ significantly inhibited 6beta-hydroxylation of testosterone in human liver microsomes by 83.9%.Note : In conclusion, pomelo constituents inhibit the activity of CYP3A4 and may thereby produce an increase in the blood level of tacrolimus. Data incomplete
