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Part Used : น้ำจากผลActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : grapefruit juiceType of experiment : humanType of animal : -Type of study : Open trialN(Total) : 11* (M/F = 6/5)N(Treatment) : 11 (M/F = 6/5)Sex : Both sexAge : 14 -43 yrs. (median 32)Route : Oral administrationDose/Conc.(herb) : There were 5 study days, each separated by 3 days of washout. A dose of 30 mg of dextromethorphan (DM) hydrobromide was taken on each study day before bedtime. Volunteers took the DM followed by 200 ml of water (Study Day 1), by 200 ml of grapefruit juice (Study Day 2), by 200 ml of water (Study Day 3), by 200 ml seville orange juice (Study Day 4) and by 200 ml of water (Study Day 5).Duration : On each of the 5 days, a spot urine sample was obtained before administration of DM and the 8-h complete urine output was colloected in the morning.Type of interaction : PharmacokineticsInteraction with drug : Dextromethorphan*/Dextromethorfan/DextromorphanDose/Conc.(drug) : A dose of 30 mg of dextromethorphan hydrobromide (contained in 10 ml of the over-the-counter cough medicine Balmini DM(R))Result : PositiveRemark :Note : *Subject total: Subjects were healthy volunteers. Result: Bioavailability of DM increased significantly with grapefruit and seville orange juice, but only returned to half the baseline value after three days of washout. This confirms that grapefruit and seville orange juice are long lasting and perhaps irreversible inhibitors of gut CYP3A/P-glycoprotein. Grapefruit and seville orange juice appeared to have the same overall effect on DM pharmacokinetics.
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : grapefruit juiceType of experiment : humanType of animal : -Type of study : Open trialN(Total) : 11* (M/F = 6/5)N(Treatment) : 11 (M/F = 6/5)Sex : Both sexAge : 14 -43 yrs. (median 32)Route : Oral administrationDose/Conc.(herb) : There were 5 study days, each separated by 3 days of washout. A dose of 30 mg of dextromethorphan (DM) hydrobromide was taken on each study day before bedtime. Volunteers took the DM followed by 200 ml of water (Study Day 1), by 200 ml of grapefruit juice (Study Day 2), by 200 ml of water (Study Day 3), by 200 ml seville orange juice (Study Day 4) and by 200 ml of water (Study Day 5).Duration : On each of the 5 days, a spot urine sample was obtained before administration of DM and the 8-h complete urine output was colloected in the morning.Type of interaction : PharmacokineticsInteraction with drug : Dextromethorphan*/Dextromethorfan/DextromorphanDose/Conc.(drug) : A dose of 30 mg of dextromethorphan hydrobromide (contained in 10 ml of the over-the-counter cough medicine Balmini DM(R))Result : PositiveRemark :Note : *Subject total: Subjects were healthy volunteers. Result: Bioavailability of DM increased significantly with grapefruit and seville orange juice, but only returned to half the baseline value after three days of washout. This confirms that grapefruit and seville orange juice are long lasting and perhaps irreversible inhibitors of gut CYP3A/P-glycoprotein. Grapefruit and seville orange juice appeared to have the same overall effect on DM pharmacokinetics.
Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : grapefruit juiceType of experiment : humanType of animal : -Type of study : Open trialN(Total) : 11* (M/F = 6/5)N(Treatment) : 11 (M/F = 6/5)Sex : Both sexAge : 14 -43 yrs. (median 32)Route : Oral administrationDose/Conc.(herb) : There were 5 study days, each separated by 3 days of washout. A dose of 30 mg of dextromethorphan (DM) hydrobromide was taken on each study day before bedtime. Volunteers took the DM followed by 200 ml of water (Study Day 1), by 200 ml of grapefruit juice (Study Day 2), by 200 ml of water (Study Day 3), by 200 ml seville orange juice (Study Day 4) and by 200 ml of water (Study Day 5).Duration : On each of the 5 days, a spot urine sample was obtained before administration of DM and the 8-h complete urine output was colloected in the morning.Type of interaction : PharmacokineticsInteraction with drug : Dextromethorphan*/Dextromethorfan/DextromorphanDose/Conc.(drug) : A dose of 30 mg of dextromethorphan hydrobromide (contained in 10 ml of the over-the-counter cough medicine Balmini DM(R))Result : PositiveRemark :Note : *Subject total: Subjects were healthy volunteers. Result: Bioavailability of DM increased significantly with grapefruit and seville orange juice, but only returned to half the baseline value after three days of washout. This confirms that grapefruit and seville orange juice are long lasting and perhaps irreversible inhibitors of gut CYP3A/P-glycoprotein. Grapefruit and seville orange juice appeared to have the same overall effect on DM pharmacokinetics.
Part Used : น้ำจากผลActivity : CYP3A INHIBITIONSolvent/Active Compound : grapefruit juiceType of experiment : humanType of animal : -Type of study : Open trialN(Total) : 11* (M/F = 6/5)N(Treatment) : 11 (M/F = 6/5)Sex : Both sexAge : 14 -43 yrs. (median 32)Route : Oral administrationDose/Conc.(herb) : There were 5 study days, each separated by 3 days of washout. A dose of 30 mg of dextromethorphan (DM) hydrobromide was taken on each study day before bedtime. Volunteers took the DM followed by 200 ml of water (Study Day 1), by 200 ml of grapefruit juice (Study Day 2), by 200 ml of water (Study Day 3), by 200 ml seville orange juice (Study Day 4) and by 200 ml of water (Study Day 5).Duration : On each of the 5 days, a spot urine sample was obtained before administration of DM and the 8-h complete urine output was colloected in the morning.Type of interaction : PharmacokineticsInteraction with drug : Dextromethorphan*/Dextromethorfan/DextromorphanDose/Conc.(drug) : A dose of 30 mg of dextromethorphan hydrobromide (contained in 10 ml of the over-the-counter cough medicine Balmini DM(R))Result : PositiveRemark :Note : *Subject total: Subjects were healthy volunteers. Result: Bioavailability of DM increased significantly with grapefruit and seville orange juice, but only returned to half the baseline value after three days of washout. This confirms that grapefruit and seville orange juice are long lasting and perhaps irreversible inhibitors of gut CYP3A/P-glycoprotein. Grapefruit and seville orange juice appeared to have the same overall effect on DM pharmacokinetics.
Part Used : น้ำจากผลActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : seville orange juiceType of experiment : humanType of animal : -Type of study : Open trialN(Total) : 11* (M/F = 6/5)N(Treatment) : 11 (M/F = 6/5)Sex : Both sexAge : 14 -43 yrs. (median 32)Route : Oral administrationDose/Conc.(herb) : There were 5 study days, each separated by 3 days of washout. A dose of 30 mg of dextromethorphan (DM) hydrobromide was taken on each study day before bedtime. Volunteers took the DM followed by 200 ml of water (Study Day 1), by 200 ml of grapefruit juice (Study Day 2), by 200 ml of water (Study Day 3), by 200 ml seville orange juice (Study Day 4) and by 200 ml of water (Study Day 5).Duration : On each of the 5 days, a spot urine sample was obtained before administration of DM and the 8-h complete urine output was colloected in the morning.Type of interaction : PharmacokineticsInteraction with drug : Dextromethorphan*/Dextromethorfan/DextromorphanDose/Conc.(drug) : A dose of 30 mg of dextromethorphan hydrobromide (contained in 10 ml of the over-the-counter cough medicine Balmini DM(R))Result : PositiveRemark :Note : *Subject total: Subjects were healthy volunteers. Result: Bioavailability of DM increased significantly with grapefruit and seville orange juice, but only returned to half the baseline value after three days of washout. This confirms that grapefruit and seville orange juice are long lasting and perhaps irreversible inhibitors of gut CYP3A/P-glycoprotein. Grapefruit and seville orange juice appeared to have the same overall effect on DM pharmacokinetics.
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : seville orange juiceType of experiment : humanType of animal : -Type of study : Open trialN(Total) : 11* (M/F = 6/5)N(Treatment) : 11 (M/F = 6/5)Sex : Both sexAge : 14 -43 yrs. (median 32)Route : Oral administrationDose/Conc.(herb) : There were 5 study days, each separated by 3 days of washout. A dose of 30 mg of dextromethorphan (DM) hydrobromide was taken on each study day before bedtime. Volunteers took the DM followed by 200 ml of water (Study Day 1), by 200 ml of grapefruit juice (Study Day 2), by 200 ml of water (Study Day 3), by 200 ml seville orange juice (Study Day 4) and by 200 ml of water (Study Day 5).Duration : On each of the 5 days, a spot urine sample was obtained before administration of DM and the 8-h complete urine output was colloected in the morning.Type of interaction : PharmacokineticsInteraction with drug : Dextromethorphan*/Dextromethorfan/DextromorphanDose/Conc.(drug) : A dose of 30 mg of dextromethorphan hydrobromide (contained in 10 ml of the over-the-counter cough medicine Balmini DM(R))Result : PositiveRemark :Note : *Subject total: Subjects were healthy volunteers. Result: Bioavailability of DM increased significantly with grapefruit and seville orange juice, but only returned to half the baseline value after three days of washout. This confirms that grapefruit and seville orange juice are long lasting and perhaps irreversible inhibitors of gut CYP3A/P-glycoprotein. Grapefruit and seville orange juice appeared to have the same overall effect on DM pharmacokinetics.
Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : seville orange juiceType of experiment : humanType of animal : -Type of study : Open trialN(Total) : 11* (M/F = 6/5)N(Treatment) : 11 (M/F = 6/5)Sex : Both sexAge : 14 -43 yrs. (median 32)Route : Oral administrationDose/Conc.(herb) : There were 5 study days, each separated by 3 days of washout. A dose of 30 mg of dextromethorphan (DM) hydrobromide was taken on each study day before bedtime. Volunteers took the DM followed by 200 ml of water (Study Day 1), by 200 ml of grapefruit juice (Study Day 2), by 200 ml of water (Study Day 3), by 200 ml seville orange juice (Study Day 4) and by 200 ml of water (Study Day 5).Duration : On each of the 5 days, a spot urine sample was obtained before administration of DM and the 8-h complete urine output was colloected in the morning.Type of interaction : PharmacokineticsInteraction with drug : Dextromethorphan*/Dextromethorfan/DextromorphanDose/Conc.(drug) : A dose of 30 mg of dextromethorphan hydrobromide (contained in 10 ml of the over-the-counter cough medicine Balmini DM(R))Result : PositiveRemark :Note : *Subject total: Subjects were healthy volunteers. Result: Bioavailability of DM increased significantly with grapefruit and seville orange juice, but only returned to half the baseline value after three days of washout. This confirms that grapefruit and seville orange juice are long lasting and perhaps irreversible inhibitors of gut CYP3A/P-glycoprotein. Grapefruit and seville orange juice appeared to have the same overall effect on DM pharmacokinetics.
Part Used : น้ำจากผลActivity : CYP3A INHIBITIONSolvent/Active Compound : seville orange juiceType of experiment : humanType of animal : -Type of study : Open trialN(Total) : 11* (M/F = 6/5)N(Treatment) : 11 (M/F = 6/5)Sex : Both sexAge : 14 -43 yrs. (median 32)Route : Oral administrationDose/Conc.(herb) : There were 5 study days, each separated by 3 days of washout. A dose of 30 mg of dextromethorphan (DM) hydrobromide was taken on each study day before bedtime. Volunteers took the DM followed by 200 ml of water (Study Day 1), by 200 ml of grapefruit juice (Study Day 2), by 200 ml of water (Study Day 3), by 200 ml seville orange juice (Study Day 4) and by 200 ml of water (Study Day 5).Duration : On each of the 5 days, a spot urine sample was obtained before administration of DM and the 8-h complete urine output was colloected in the morning.Type of interaction : PharmacokineticsInteraction with drug : Dextromethorphan*/Dextromethorfan/DextromorphanDose/Conc.(drug) : A dose of 30 mg of dextromethorphan hydrobromide (contained in 10 ml of the over-the-counter cough medicine Balmini DM(R))Result : PositiveRemark :Note : *Subject total: Subjects were healthy volunteers. Result: Bioavailability of DM increased significantly with grapefruit and seville orange juice, but only returned to half the baseline value after three days of washout. This confirms that grapefruit and seville orange juice are long lasting and perhaps irreversible inhibitors of gut CYP3A/P-glycoprotein. Grapefruit and seville orange juice appeared to have the same overall effect on DM pharmacokinetics.
