Part Used : ไม่ระบุ
Activity : DRUG INTERACTION
Solvent/Active Compound : Ferulic acid
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : 0-100 micromolar
Duration : 24-48 hours
Type of interaction : Pharmacodynamics
Interaction with drug : Metformin
Dose/Conc.(drug) : 0-100 micromolar
Remark : - Metformin (20 micromolar) with ferulic acid (25 micromolar), eugenol (25 micromolar), chlorogenic acid (25 micromolar), p-coumaric acid (25 micromolar), caffeic acid (25 micromolar), and cinnamic acid (25 micromolar) increased 2DG uptake by 6.5-, 6.4-, 6.2-, 6.1-, 6.3-, and 5.9-fold, respectively, when compared to control.
- All of the phytochemicals, except cinnamic acid, showed synergistic behavior with both the OHDs in the uptake of 2DG, whereas cinnamic acid exhibited an additive effect.
Note : The effect of cinnamic acid, ferulic acid, p-coumaric acid, eugenol, chlorogenic acid, and caffeic acid, alone and in combination with two commercial oral hypoglycemic drugs (OHD), namely, thiazolidinedione (THZ) and metformin on the uptake of 2-deoxyglucose (2DG) by 3T3-L1 adipocytes is studied.