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CUCURBITACEAE Cucurbita spp.

Synonym

none ...

Thai / English name

Cucurbita spp.

[1-1] of 1 article(s) found

หน้า 1

[1] ENHANCING ACTIVITY OF ANTICANCER DRUGS IN MULTIDRUG RESISTANT TUMORS BY MODULATING P-GLYCOPROTEIN THROUGH DIETARY NUTRACEUTICALS.
MUHAMMAD KHAN,AMARA MARYAM,TAHIR MEHMOOD,ET AL.
ASIAN PAC J CANCER PREV 2015 Vol.16(16),6831-9 $59875 [Full]

Part Used : ผล
Activity : DRUG INTERACTION

Solvent/Active Compound : Beta-carotene

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Doxorubicin*/Adrimycin/ADR/Adria
Dose/Conc.(drug) : -

Result : Positive

Remark : Beta-Carotene has accumulated Rhodamine 123, calcein AM, and doxorubicin in Caco-2 cell dose dependently. It also stimulated the efficacy of 5-Fluorouracil, doxorubicin, and eteposide in Caco-2 cells. Its impact on resistance mechanism involved downregulation of MDR1 gene expression and inhibition of p-glycoprotein transport activity in Caco-2 cells.

Note : Data from review

Part Used : ผล
Activity : P-GLYCOPROTEIN INHIBITION

Solvent/Active Compound : Beta-carotene

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Doxorubicin*/Adrimycin/ADR/Adria
Dose/Conc.(drug) : -

Result : Positive

Remark : Beta-Carotene has accumulated Rhodamine 123, calcein AM, and doxorubicin in Caco-2 cell dose dependently. It also stimulated the efficacy of 5-Fluorouracil, doxorubicin, and eteposide in Caco-2 cells. Its impact on resistance mechanism involved downregulation of MDR1 gene expression and inhibition of p-glycoprotein transport activity in Caco-2 cells.

Note : Data from review

หน้า 1

EN

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