ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ใบ

Activity : DRUG INTERACTION

Solvent/Active Compound : methanol

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : 32 microgram/ml

Duration : -

Type of interaction : Pharmacodynamics

Interaction with drug : Norfloxacin

Dose/Conc.(drug) : 2.5-0.0012 mg/ml

Result : Positive

Remark : The antibiotic activity of norfloxacin was enhanced when this antibiotic was conbined with sub-inhibitory concentrations of extracts, mainly the hexane extracts.

Note : Minimal inhibitory concentration (MIC) was determined in a microdillution assay utilizing an inoculums of 100 microlitre of each strain, suspended in brain heart infusion (BHI) broth up to a final concentration of 10^5 CFU/ml in 96-well microliter plates. The final concentrations of antibiotic drug concentration range of 2.5-0.0012 mg/ml. MIC of the antibiotics was determined in the presence of absence of extracts at sub-inhibitory concentrations (32 microlitre/ml) and the plates were incubated for 24 h at 37 degress celsius. Each antibacterial assay for MIC determination was carried out in triplicate.

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