ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ดูหมายเหตุ

Activity : DRUG INTERACTION

Solvent/Active Compound : Pallidifloside D

Type of experiment : in vivo

Type of animal : mouse

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Oral administration

Dose/Conc.(herb) : 5 mg/kg

Duration : 7 days

Type of interaction : P.Kinetics & P.Dynamics

Interaction with drug : Allopurinol

Dose/Conc.(drug) : 5 mg/kg

Result : Positive

Remark : The combination of allopurinol and Pallidifloside D significantly decreased the serum uric acid level and increased the urine uric acid level, leading to the normalized serum and urine uric acid concentrations. After Pallidifloside D plus allopurinol, the serum creatinine, urine creatinine and BUN levels were significantly reduced. The synergistic effects of allopurinol combined with Pallidifloside D were linked to the inhibition of both serum and hepatic xanthine oxidase (XOD), the down-regulation of renal mURAT1 and mGLUT9, and the up-regulation of mOAT1.

Note : Type of exteriment: Hyperuricemia mice were divided into control; model group, induced with potassium oxonate; allopurinol (5 mg/kg); Pallidifloside D (5 mg/kg); and allopurinol (5 mg/kg) plus Pallidifloside D (5 mg/kg) group. *Part used: root and rhizome

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