Synonym |
Thai / English name |
Part Used : ดูหมายเหตุActivity : OATP (ORGANIC ANION TRANSPORTER PROTEIN) INDUCTIONSolvent/Active Compound : Pallidifloside DType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 5 mg/kgDuration : 7 daysType of interaction : P.Kinetics & P.DynamicsInteraction with drug : AllopurinolDose/Conc.(drug) : 5 mg/kgResult : PositiveRemark : The combination of allopurinol and Pallidifloside D significantly decreased the serum uric acid level and increased the urine uric acid level, leading to the normalized serum and urine uric acid concentrations. After Pallidifloside D plus allopurinol, the serum creatinine, urine creatinine and BUN levels were significantly reduced. The synergistic effects of allopurinol combined with Pallidifloside D were linked to the inhibition of both serum and hepatic xanthine oxidase (XOD), the down-regulation of renal mURAT1 and mGLUT9, and the up-regulation of mOAT1.Note : Type of exteriment: Hyperuricemia mice were divided into control; model group, induced with potassium oxonate; allopurinol (5 mg/kg); Pallidifloside D (5 mg/kg); and allopurinol (5 mg/kg) plus Pallidifloside D (5 mg/kg) group. *Part used: root and rhizome
Part Used : ดูหมายเหตุActivity : XANTHINE OXIDASE INHIBITIONSolvent/Active Compound : Pallidifloside DType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 5 mg/kgDuration : 7 daysType of interaction : P.Kinetics & P.DynamicsInteraction with drug : AllopurinolDose/Conc.(drug) : 5 mg/kgResult : PositiveRemark : The combination of allopurinol and Pallidifloside D significantly decreased the serum uric acid level and increased the urine uric acid level, leading to the normalized serum and urine uric acid concentrations. After Pallidifloside D plus allopurinol, the serum creatinine, urine creatinine and BUN levels were significantly reduced. The synergistic effects of allopurinol combined with Pallidifloside D were linked to the inhibition of both serum and hepatic xanthine oxidase (XOD), the down-regulation of renal mURAT1 and mGLUT9, and the up-regulation of mOAT1.Note : Type of exteriment: Hyperuricemia mice were divided into control; model group, induced with potassium oxonate; allopurinol (5 mg/kg); Pallidifloside D (5 mg/kg); and allopurinol (5 mg/kg) plus Pallidifloside D (5 mg/kg) group. *Part used: root and rhizome
Part Used : ดูหมายเหตุActivity : BUN LOWERING EFFECTSolvent/Active Compound : Pallidifloside DType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 5 mg/kgDuration : 7 daysType of interaction : P.Kinetics & P.DynamicsInteraction with drug : AllopurinolDose/Conc.(drug) : 5 mg/kgResult : PositiveRemark : The combination of allopurinol and Pallidifloside D significantly decreased the serum uric acid level and increased the urine uric acid level, leading to the normalized serum and urine uric acid concentrations. After Pallidifloside D plus allopurinol, the serum creatinine, urine creatinine and BUN levels were significantly reduced. The synergistic effects of allopurinol combined with Pallidifloside D were linked to the inhibition of both serum and hepatic xanthine oxidase (XOD), the down-regulation of renal mURAT1 and mGLUT9, and the up-regulation of mOAT1.Note : Type of exteriment: Hyperuricemia mice were divided into control; model group, induced with potassium oxonate; allopurinol (5 mg/kg); Pallidifloside D (5 mg/kg); and allopurinol (5 mg/kg) plus Pallidifloside D (5 mg/kg) group. *Part used: root and rhizome
Part Used : ดูหมายเหตุActivity : DRUG INTERACTIONSolvent/Active Compound : Pallidifloside DType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 5 mg/kgDuration : 7 daysType of interaction : P.Kinetics & P.DynamicsInteraction with drug : AllopurinolDose/Conc.(drug) : 5 mg/kgResult : PositiveRemark : The combination of allopurinol and Pallidifloside D significantly decreased the serum uric acid level and increased the urine uric acid level, leading to the normalized serum and urine uric acid concentrations. After Pallidifloside D plus allopurinol, the serum creatinine, urine creatinine and BUN levels were significantly reduced. The synergistic effects of allopurinol combined with Pallidifloside D were linked to the inhibition of both serum and hepatic xanthine oxidase (XOD), the down-regulation of renal mURAT1 and mGLUT9, and the up-regulation of mOAT1.Note : Type of exteriment: Hyperuricemia mice were divided into control; model group, induced with potassium oxonate; allopurinol (5 mg/kg); Pallidifloside D (5 mg/kg); and allopurinol (5 mg/kg) plus Pallidifloside D (5 mg/kg) group. *Part used: root and rhizome
Part Used : ดูหมายเหตุActivity : URIC ACID DECREASESolvent/Active Compound : Pallidifloside DType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 5 mg/kgDuration : 7 daysType of interaction : P.Kinetics & P.DynamicsInteraction with drug : AllopurinolDose/Conc.(drug) : 5 mg/kgResult : PositiveRemark : The combination of allopurinol and Pallidifloside D significantly decreased the serum uric acid level and increased the urine uric acid level, leading to the normalized serum and urine uric acid concentrations. After Pallidifloside D plus allopurinol, the serum creatinine, urine creatinine and BUN levels were significantly reduced. The synergistic effects of allopurinol combined with Pallidifloside D were linked to the inhibition of both serum and hepatic xanthine oxidase (XOD), the down-regulation of renal mURAT1 and mGLUT9, and the up-regulation of mOAT1.Note : Type of exteriment: Hyperuricemia mice were divided into control; model group, induced with potassium oxonate; allopurinol (5 mg/kg); Pallidifloside D (5 mg/kg); and allopurinol (5 mg/kg) plus Pallidifloside D (5 mg/kg) group. *Part used: root and rhizome
Part Used : ดูหมายเหตุActivity : CREATININE LEVEL DECREASESolvent/Active Compound : Pallidifloside DType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 5 mg/kgDuration : 7 daysType of interaction : P.Kinetics & P.DynamicsInteraction with drug : AllopurinolDose/Conc.(drug) : 5 mg/kgResult : PositiveRemark : The combination of allopurinol and Pallidifloside D significantly decreased the serum uric acid level and increased the urine uric acid level, leading to the normalized serum and urine uric acid concentrations. After Pallidifloside D plus allopurinol, the serum creatinine, urine creatinine and BUN levels were significantly reduced. The synergistic effects of allopurinol combined with Pallidifloside D were linked to the inhibition of both serum and hepatic xanthine oxidase (XOD), the down-regulation of renal mURAT1 and mGLUT9, and the up-regulation of mOAT1.Note : Type of exteriment: Hyperuricemia mice were divided into control; model group, induced with potassium oxonate; allopurinol (5 mg/kg); Pallidifloside D (5 mg/kg); and allopurinol (5 mg/kg) plus Pallidifloside D (5 mg/kg) group. *Part used: root and rhizome