Part Used : ไม่ระบุ
Activity : CYP2D6 INHIBITION
Solvent/Active Compound : methysticin
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : 200 micromolar
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : -
Dose/Conc.(drug) :
Remark : Results:
lC50 values (micromolar) of test compounds for CYP1A2 inhibition = 12.53 micromolar
lC50 values (micromolar) of test compounds for CYP2C9 inhibition = 16.39 micromolar
lC50 values (micromolar) of test compounds for CYP2C19 inhibition = 0.93 micromolar
lC50 values (micromolar) of test compounds for CYP2D6 inhibition = 153.20 micromolar
lC50 values (micromolar) of test compounds for CYP3A4 (BzRes) inhibition = 10.20 micromolar
lC50 values (micromolar) of test compounds for CYP3A4 (BFC) inhibition = 1.49 micromolar
Note : Evaluated the effects of 25 purified components of commonly used herbal products on the catalytic activity of cDNA-expressed cytochrome P450 isoforms in in vitro experiments. Increasing concentrations of the compounds were incubated with a panel of recombinant human CYP isoforms (CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4) and their effects on the conversion of specific surrogate substrates measured fluorometrically in a 96-well plate format.