ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ราก

Activity : PHARMACOKINETIC ALTERATION

Solvent/Active Compound : 18beta-glycyrrhetic acid (18beta-GA)

Type of experiment : in vivo

Type of animal : rat

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Oral administration

Dose/Conc.(herb) : A single dose of emodin at 11 mg/kg (0.5% sodium CMC), Digoxin at a dose of 0.25 mg/kg was given to the rats by oral administration 30 min after pre-treatment with inhibitors.

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : Digoxin

Dose/Conc.(drug) : -

Result : Positive

Remark : Result: Co-administration of digoxin with verapamil or emodin can increase the AUC0-t of digoxin by 55% and 51%, respectively. When digoxin was co-administered with verapamil or 18beta-GA, the Cmax of digoxin was increased by 150% and 58%, respectively. In addition, the volume of distribution (Vd/F) and total body clearance of digoxin (CL/F) of digoxin were both decreased after pretreatment with verapamil or emodin in rats.

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