Part Used : -
Activity : CYP1B1 INHIBITION
Solvent/Active Compound : licochalcone A (LicA), isoliquiritigenin (Lig C)
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : -
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : -
Dose/Conc.(drug) : -
Remark : Glycyrrhiza inflate (GI) which specially contain LicA and has the highest levels of LigC equivalents, inhibited iNOS activity more strongly compared to the other species. Glycyrrhiza inflate and LicA reduced P450 1B1 mRNA levels with and without cytokines, yet G. glabra, G. uralensis and LigC with cytokines additively increased its expression.