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LEGUMINOSAE (FABACEAE) - PAPILIONOIDEAE Glycyrrhiza spp.

Synonym

none ...

Thai / English name

Glycyrrhiza spp.

[1-1] of 1 article(s) found

หน้า 1

[1] INHIBITORY EFFECTS OF HERBAL CONSTITUENTS ON P-GLYCOPROTEIN IN VITRO AND IN VIVO: HERB-DRUG INTERACTIONS MEDIATED VIA P-GP.
LI,XUE;HU,JINPING;WANG,BAOLIAN;ET AL.
TOXICOL APPL PHARMACOL 2014 Vol.275(2),163-75 $53165 [Full]

Part Used : ราก
Activity : CYP3A INHIBITION

Solvent/Active Compound : 18 beta-glycyrrhetic acid (18beta-GA)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 10 micromolars

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Midazolam*/Versed/Dormicum
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: Human liver microsomes Result: 18 beta-GA, DAG, 20(S)-GF1 and Rh1 significantly inhibited CYP3A activity (44, 41, 23 and 15% inhibition, respectively)

Part Used : ราก
Activity : CYP3A INHIBITION

Solvent/Active Compound : 18 alpha-glycyrrhetic acid (18 alpha-GA)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 10 micromolars

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Midazolam*/Versed/Dormicum
Dose/Conc.(drug) : -

Result : Negative

Remark : Type of experiment: Human liver microsomes Result: 18alpha-GA and AG did not show statistical inhibition on the formation rate of 1'-hydroxymidazolam.

หน้า 1

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