| Synonym |
| Thai / English name |
Part Used : เหง้าActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : hydroethanolicType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 20-40 micrograms/mlDuration : -Type of interaction : PharmacodynamicsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Both Curcuma longa and Curcuma sp. "Khamin-oi" extracts increased the amount of R123 accumulation in both wild-type and vinblastine-selected Caco-2 calls in a concentration-dependent manner.
Part Used : เหง้าActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : curcuminType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 25 micrograms/mlDuration : -Type of interaction : PharmacodynamicsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Curcumin and demethoxycurcumin significantly increased calcein-AM uptake in both cell lines in cencentration-dependent manner but the increment observed in LLC-GA5-COL300 was markedly higher than that of LLC-PK1. Bisdemethoxycurcumin did not alter the calcain-AM uptake in both LLC-PK1 and LLC-GA5-COL300, implying that dismethoxuycurcumin could not affect the P-pg function.
Part Used : เหง้าActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : demethoxycurcuminType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 35 micrograms/mlDuration : -Type of interaction : PharmacodynamicsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Curcumin and demethoxycurcumin significantly increased calcein-AM uptake in both cell lines in cencentration-dependent manner but the increment observed in LLC-GA5-COL300 was markedly higher than that of LLC-PK1. Bisdemethoxycurcumin did not alter the calcain-AM uptake in both LLC-PK1 and LLC-GA5-COL300, implying that dismethoxuycurcumin could not affect the P-pg function.
Part Used : เหง้าActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : bisdemethoxycurcuminType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 50 micrograms/mlDuration : -Type of interaction : PharmacodynamicsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Curcumin and demethoxycurcumin significantly increased calcein-AM uptake in both cell lines in cencentration-dependent manner but the increment observed in LLC-GA5-COL300 was markedly higher than that of LLC-PK1. Bisdemethoxycurcumin did not alter the calcain-AM uptake in both LLC-PK1 and LLC-GA5-COL300, implying that dismethoxuycurcumin could not affect the P-pg function.
