| Synonym |
| Thai / English name |
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : antraquinoneType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : Rhuem emodi 0.4 g/kgDuration : 24 h before CCl4 administrationType of interaction : PharmacodynamicsInteraction with drug : -Dose/Conc.(drug) : -Result : -Remark : Oral dose of total anthraquinone fraction of Rhuem emodi 0.4 g/kg significantly prevent the CCl4 induced prolongation sleep time when compared to the control, indicating that Rhuem emodi against CCL4 induced cytochrome P450 damage.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : rheinType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 100 mg/kg rheinDuration : *Type of interaction : PharmacokineticsInteraction with drug : Furosemide*/FrusemideDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : Duration* - For the interaction by rhein, a dose of 100 mg/kg rhein was given by gavage 5 min before administration of 10 mg/kg furosemide (FS) intravenously through the tail vein. Results: indicated that pre-treatment with rhein significantly attered the pharmacokinetics of FS in rats.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : waterType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 5 g crude drug/kg/dayDuration : *Type of interaction : PharmacokineticsInteraction with drug : Furosemide*/FrusemideDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : Duration* - Single-dose of rhubarb extract (RE) was administrated by gavage 5 min before administration of furosemide (FS). - Single-dose coadministration with RE seemed to inhibit FS in rat well. The area under the curve (AUCo-t) values of FS were increased by 32%.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : waterType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 5 g crude drug/kg/dayDuration : *Type of interaction : PharmacokineticsInteraction with drug : Furosemide*/FrusemideDose/Conc.(drug) : -Result : PositiveRemark : Duration* - Multiple-dose of rhubarb extract (RE) was administrated for six consecutive days and administrated of furosemide (FS) at the seventh day. - Multiple-dose coadministration with RE seemed to inhibit FS in rats as well. The area under the curve (AUC0-t) values of FS were increased by 52%.
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : Emodin, chrysophanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 50 micromolarsDuration : -Type of interaction : PharmacokineticsInteraction with drug : DigoxinDose/Conc.(drug) : -Result : PositiveRemark : Result: The inhibitory effects on P-gp mediated digoxin transport were investigated in MDR1-MDCKII cells. Emodin, 18 beta-GA, DAG, and 20 (S)-GF1 exhibited significant inhibition (> 50%) on P-gp. However, the isomers or analogs of the 4 herbal constituents (chrysophanol, 18alpha-GA, AG, and Rh1) and the remaining tested compounds relatively weak inhibition on digoxin transport in this cell model. The concentraion-dependent inhibition on P-gp-mediated digoxin transport was further investigated for emodin, 18beta-GA, DAG, and 20(S)-GF1. Emodin was the strongest herbal inhibitor of P-gp, followed by 18beta-GA, 20(S)-GF1 and DAG. Consistent with the data obtained from MDR1-MDCKII cells, emodin, 18 beta-GA, DAG, and 20(S)-GF1 significantly inhibited digoxin transport (>50%), while chrysophanol, 18alpha-GA, AG, and Rh1 showed no effects or relatively weak inhibition on P-gp.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : emodin, Chrysophanol, physcion, rheinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.01-25 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: human hepatic HepG2 and/or Huh7 cells Results: Emodin and morin (conc. 25 micromolar) can effectively activate pregnane X receptor (PXR) in human hepatic HepG2 and/or Huh7 cells. Chrysophanol, physcion, and rhein are also potential activators of PXR.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : emodin, physicon, rheinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 1 and 25 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: LS174T cell lines Results: Emodin, physcion, and rhein significantly induce CYP3A4 mRNA expression in human intestinal LS174T cells. However, mulberroside A significantly down-regulate the expression of PXR in human intestinal LS174T cells.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mg/kgDuration : 7 daysType of interaction : PharmacokineticsInteraction with drug : ClozapineDose/Conc.(drug) : 100 mg/kgResult : PositiveRemark : With rhein 10 mg/kg for 7 days, the AUC of clozapine, but not norclozapine, increased by 2.3-fold compared with clozapine 100 mg/kg alone. In addition, the Cmax of clozapine significantly increased by 2.7-fold in combination with rhein pretreatment.Note : Pretreatment with rhein for 7 days increased the total blood concentration of clozapine, but significantly reduced the unbound clozapine concentrations in the medial prefrontal cortex (mPFC) by approximately 3-fold. Furthermore, 7 days of rhein pretreatment thoroughly abolished the efflux of dopamine and its metabolite (3,4-dihydroxyphenylacetic acid) and altered the profile of homovanillic acid, another metabolite of dopamine, in the mPFC.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mg/kgDuration : 7 daysType of interaction : P.Kinetics & P.DynamicsInteraction with drug : ClozapineDose/Conc.(drug) : 100 mg/kgResult : PositiveRemark : Type of experiment: rat plasmaNote : Pretreatment with rhein for 7 days increased the total blood concentration of clozapine, but significantly reduced the unbound clozapine concentrations in the medial prefrontal cortex (mPFC) by approximately 3-fold. Furthermore, 7 days of rhein pretreatment thoroughly abolished the efflux of dopamine and its metabolite (3,4-dihydroxyphenylacetic acid) and altered the profile of homovanillic acid, another metabolite of dopamine, in the mPFC.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1 mg/kgDuration : 7 daysType of interaction : P.Kinetics & P.DynamicsInteraction with drug : ClozapineDose/Conc.(drug) : 100 mg/kgResult : PositiveRemark : Type of experiment: rat medial prefrontal cortexNote : Pretreatment with rhein for 7 days increased the total blood concentration of clozapine, but significantly reduced the unbound clozapine concentrations in the medial prefrontal cortex (mPFC) by approximately 3-fold. Furthermore, 7 days of rhein pretreatment thoroughly abolished the efflux of dopamine and its metabolite (3,4-dihydroxyphenylacetic acid) and altered the profile of homovanillic acid, another metabolite of dopamine, in the mPFC.
