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Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : rheinType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 100 mg/kg rheinDuration : *Type of interaction : PharmacokineticsInteraction with drug : Furosemide*/FrusemideDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : Duration* - For the interaction by rhein, a dose of 100 mg/kg rhein was given by gavage 5 min before administration of 10 mg/kg furosemide (FS) intravenously through the tail vein. Results: indicated that pre-treatment with rhein significantly attered the pharmacokinetics of FS in rats.
Part Used : เหง้าActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : waterType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 5 g crude drug/kg/dayDuration : *Type of interaction : PharmacokineticsInteraction with drug : Furosemide*/FrusemideDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : Duration* - Single-dose of rhubarb extract (RE) was administrated by gavage 5 min before administration of furosemide (FS). - Single-dose coadministration with RE seemed to inhibit FS in rat well. The area under the curve (AUCo-t) values of FS were increased by 32%.
Part Used : เหง้าActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : waterType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 5 g crude drug/kg/dayDuration : *Type of interaction : PharmacokineticsInteraction with drug : Furosemide*/FrusemideDose/Conc.(drug) : -Result : PositiveRemark : Duration* - Multiple-dose of rhubarb extract (RE) was administrated for six consecutive days and administrated of furosemide (FS) at the seventh day. - Multiple-dose coadministration with RE seemed to inhibit FS in rats as well. The area under the curve (AUC0-t) values of FS were increased by 52%.
Part Used : รากActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : emodinType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : A single dose of emodin at 11 mg/kg (0.5% sodium CMC), Digoxin at a dose of 0.25 mg/kg was given to the rats by oral administration 30 min after pre-treatment with inhibitors.Duration : -Type of interaction : PharmacokineticsInteraction with drug : DigoxinDose/Conc.(drug) : -Result : PositiveRemark : Result: Co-administration of digoxin with verapamil or emodin can increase the AUC0-t of digoxin by 55% and 51%, respectively. When digoxin was co-administered with verapamil or 18beta-GA, the Cmax of digoxin was increased by 150% and 58%, respectively. In addition, the volume of distribution (Vd/F) and total body clearance of digoxin (CL/F) of digoxin were both decreased after pretreatment with verapamil or emodin in rats.
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mg/kgDuration : 7 daysType of interaction : PharmacokineticsInteraction with drug : ClozapineDose/Conc.(drug) : 100 mg/kgResult : PositiveRemark : With rhein 10 mg/kg for 7 days, the AUC of clozapine, but not norclozapine, increased by 2.3-fold compared with clozapine 100 mg/kg alone. In addition, the Cmax of clozapine significantly increased by 2.7-fold in combination with rhein pretreatment.Note : Pretreatment with rhein for 7 days increased the total blood concentration of clozapine, but significantly reduced the unbound clozapine concentrations in the medial prefrontal cortex (mPFC) by approximately 3-fold. Furthermore, 7 days of rhein pretreatment thoroughly abolished the efflux of dopamine and its metabolite (3,4-dihydroxyphenylacetic acid) and altered the profile of homovanillic acid, another metabolite of dopamine, in the mPFC.
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mg/kgDuration : 7 daysType of interaction : P.Kinetics & P.DynamicsInteraction with drug : ClozapineDose/Conc.(drug) : 100 mg/kgResult : PositiveRemark : Type of experiment: rat plasmaNote : Pretreatment with rhein for 7 days increased the total blood concentration of clozapine, but significantly reduced the unbound clozapine concentrations in the medial prefrontal cortex (mPFC) by approximately 3-fold. Furthermore, 7 days of rhein pretreatment thoroughly abolished the efflux of dopamine and its metabolite (3,4-dihydroxyphenylacetic acid) and altered the profile of homovanillic acid, another metabolite of dopamine, in the mPFC.
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1 mg/kgDuration : 7 daysType of interaction : P.Kinetics & P.DynamicsInteraction with drug : ClozapineDose/Conc.(drug) : 100 mg/kgResult : PositiveRemark : Type of experiment: rat medial prefrontal cortexNote : Pretreatment with rhein for 7 days increased the total blood concentration of clozapine, but significantly reduced the unbound clozapine concentrations in the medial prefrontal cortex (mPFC) by approximately 3-fold. Furthermore, 7 days of rhein pretreatment thoroughly abolished the efflux of dopamine and its metabolite (3,4-dihydroxyphenylacetic acid) and altered the profile of homovanillic acid, another metabolite of dopamine, in the mPFC.
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mg/kgDuration : 7 daysType of interaction : P.Kinetics & P.DynamicsInteraction with drug : ClozapineDose/Conc.(drug) : 100 mg/kgResult : PositiveRemark : Type of experiment: rat medial prefrontal cortexNote : Pretreatment with rhein for 7 days increased the total blood concentration of clozapine, but significantly reduced the unbound clozapine concentrations in the medial prefrontal cortex (mPFC) by approximately 3-fold. Furthermore, 7 days of rhein pretreatment thoroughly abolished the efflux of dopamine and its metabolite (3,4-dihydroxyphenylacetic acid) and altered the profile of homovanillic acid, another metabolite of dopamine, in the mPFC.
