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| Thai / English name |
Part Used : ไม่ระบุActivity : CYP3A4 INDUCTIONSolvent/Active Compound : Aloe-emodinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 2.5-40 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : The CYP3A4 reporter gene construct was mildly transactivated by praeruptorin E, emodin, chrysophanol, epifriedelanol, mulberroside A, physcion, salvianolic acid B, and tanshinone llA, although they didn't show significant difference as compared to control group. The CYP3A4 reporter gene construct was no transactivated by other herbal compounds.Note : Type of experiment: LS174T cells
Part Used : ไม่ระบุActivity : CYP3A4 INDUCTIONSolvent/Active Compound : chrysophanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 2.5-40 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : The CYP3A4 reporter gene construct was mildly transactivated by praeruptorin E, emodin, chrysophanol, epifriedelanol, mulberroside A, physcion, salvianolic acid B, and tanshinone llA, although they didn't show significant difference as compared to control group. The CYP3A4 reporter gene construct was no transactivated by other herbal compounds.Note : Type of experiment: LS174T cells
Part Used : ไม่ระบุActivity : CYP3A4 INDUCTIONSolvent/Active Compound : emodinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 2.5-40 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : The CYP3A4 reporter gene construct was mildly transactivated by praeruptorin E, emodin, chrysophanol, epifriedelanol, mulberroside A, physcion, salvianolic acid B, and tanshinone llA, although they didn't show significant difference as compared to control group. The CYP3A4 reporter gene construct was no transactivated by other herbal compounds.Note : Type of experiment: LS174T cells
Part Used : ไม่ระบุActivity : CYP3A4 INDUCTIONSolvent/Active Compound : physcionType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 2.5-40 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : The CYP3A4 reporter gene construct was mildly transactivated by praeruptorin E, emodin, chrysophanol, epifriedelanol, mulberroside A, physcion, salvianolic acid B, and tanshinone llA, although they didn't show significant difference as compared to control group. The CYP3A4 reporter gene construct was no transactivated by other herbal compounds.Note : Type of experiment: LS174T cells
Part Used : ไม่ระบุActivity : CYP3A4 INDUCTIONSolvent/Active Compound : rheinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 2.5-40 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : The CYP3A4 reporter gene construct was mildly transactivated by praeruptorin E, emodin, chrysophanol, epifriedelanol, mulberroside A, physcion, salvianolic acid B, and tanshinone llA, although they didn't show significant difference as compared to control group. The CYP3A4 reporter gene construct was no transactivated by other herbal compounds.Note : Type of experiment: LS174T cells
Part Used : ไม่ระบุActivity : CYP3A4 INDUCTIONSolvent/Active Compound : emodin, Chrysophanol, physcion, rheinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.01-25 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: human hepatic HepG2 and/or Huh7 cells Results: Emodin and morin (conc. 25 micromolar) can effectively activate pregnane X receptor (PXR) in human hepatic HepG2 and/or Huh7 cells. Chrysophanol, physcion, and rhein are also potential activators of PXR.
Part Used : ไม่ระบุActivity : CYP3A4 INDUCTIONSolvent/Active Compound : emodin, physicon, rheinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 1 and 25 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: LS174T cell lines Results: Emodin, physcion, and rhein significantly induce CYP3A4 mRNA expression in human intestinal LS174T cells. However, mulberroside A significantly down-regulate the expression of PXR in human intestinal LS174T cells.
