| Synonym |
| Thai / English name |
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : rheinType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 100 mg/kg rheinDuration : *Type of interaction : PharmacokineticsInteraction with drug : Furosemide*/FrusemideDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : Duration* - For the interaction by rhein, a dose of 100 mg/kg rhein was given by gavage 5 min before administration of 10 mg/kg furosemide (FS) intravenously through the tail vein. Results: indicated that pre-treatment with rhein significantly attered the pharmacokinetics of FS in rats.
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : rheinType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 100 mg/kg rheinDuration : *Type of interaction : PharmacokineticsInteraction with drug : Furosemide*/FrusemideDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : Duration* - For the interaction by rhein, a dose of 100 mg/kg rhein was given by gavage 5 min before administration of 10 mg/kg furosemide (FS) intravenously through the tail vein. Results: indicated that pre-treatment with rhein significantly attered the pharmacokinetics of FS in rats.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : waterType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 5 g crude drug/kg/dayDuration : *Type of interaction : PharmacokineticsInteraction with drug : Furosemide*/FrusemideDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : Duration* - Single-dose of rhubarb extract (RE) was administrated by gavage 5 min before administration of furosemide (FS). - Single-dose coadministration with RE seemed to inhibit FS in rat well. The area under the curve (AUCo-t) values of FS were increased by 32%.
Part Used : เหง้าActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : waterType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 5 g crude drug/kg/dayDuration : *Type of interaction : PharmacokineticsInteraction with drug : Furosemide*/FrusemideDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : Duration* - Single-dose of rhubarb extract (RE) was administrated by gavage 5 min before administration of furosemide (FS). - Single-dose coadministration with RE seemed to inhibit FS in rat well. The area under the curve (AUCo-t) values of FS were increased by 32%.
Part Used : เหง้าActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : waterType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 5 g crude drug/kg/dayDuration : *Type of interaction : PharmacokineticsInteraction with drug : Furosemide*/FrusemideDose/Conc.(drug) : -Result : PositiveRemark : Duration* - Multiple-dose of rhubarb extract (RE) was administrated for six consecutive days and administrated of furosemide (FS) at the seventh day. - Multiple-dose coadministration with RE seemed to inhibit FS in rats as well. The area under the curve (AUC0-t) values of FS were increased by 52%.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : waterType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 5 g crude drug/kg/dayDuration : *Type of interaction : PharmacokineticsInteraction with drug : Furosemide*/FrusemideDose/Conc.(drug) : -Result : PositiveRemark : Duration* - Multiple-dose of rhubarb extract (RE) was administrated for six consecutive days and administrated of furosemide (FS) at the seventh day. - Multiple-dose coadministration with RE seemed to inhibit FS in rats as well. The area under the curve (AUC0-t) values of FS were increased by 52%.
