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Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mg/kgDuration : 7 daysType of interaction : PharmacokineticsInteraction with drug : ClozapineDose/Conc.(drug) : 100 mg/kgResult : PositiveRemark : With rhein 10 mg/kg for 7 days, the AUC of clozapine, but not norclozapine, increased by 2.3-fold compared with clozapine 100 mg/kg alone. In addition, the Cmax of clozapine significantly increased by 2.7-fold in combination with rhein pretreatment.Note : Pretreatment with rhein for 7 days increased the total blood concentration of clozapine, but significantly reduced the unbound clozapine concentrations in the medial prefrontal cortex (mPFC) by approximately 3-fold. Furthermore, 7 days of rhein pretreatment thoroughly abolished the efflux of dopamine and its metabolite (3,4-dihydroxyphenylacetic acid) and altered the profile of homovanillic acid, another metabolite of dopamine, in the mPFC.
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mg/kgDuration : 7 daysType of interaction : PharmacokineticsInteraction with drug : ClozapineDose/Conc.(drug) : 100 mg/kgResult : PositiveRemark : With rhein 10 mg/kg for 7 days, the AUC of clozapine, but not norclozapine, increased by 2.3-fold compared with clozapine 100 mg/kg alone. In addition, the Cmax of clozapine significantly increased by 2.7-fold in combination with rhein pretreatment.Note : Pretreatment with rhein for 7 days increased the total blood concentration of clozapine, but significantly reduced the unbound clozapine concentrations in the medial prefrontal cortex (mPFC) by approximately 3-fold. Furthermore, 7 days of rhein pretreatment thoroughly abolished the efflux of dopamine and its metabolite (3,4-dihydroxyphenylacetic acid) and altered the profile of homovanillic acid, another metabolite of dopamine, in the mPFC.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mg/kgDuration : 7 daysType of interaction : P.Kinetics & P.DynamicsInteraction with drug : ClozapineDose/Conc.(drug) : 100 mg/kgResult : PositiveRemark : Type of experiment: rat plasmaNote : Pretreatment with rhein for 7 days increased the total blood concentration of clozapine, but significantly reduced the unbound clozapine concentrations in the medial prefrontal cortex (mPFC) by approximately 3-fold. Furthermore, 7 days of rhein pretreatment thoroughly abolished the efflux of dopamine and its metabolite (3,4-dihydroxyphenylacetic acid) and altered the profile of homovanillic acid, another metabolite of dopamine, in the mPFC.
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mg/kgDuration : 7 daysType of interaction : P.Kinetics & P.DynamicsInteraction with drug : ClozapineDose/Conc.(drug) : 100 mg/kgResult : PositiveRemark : Type of experiment: rat plasmaNote : Pretreatment with rhein for 7 days increased the total blood concentration of clozapine, but significantly reduced the unbound clozapine concentrations in the medial prefrontal cortex (mPFC) by approximately 3-fold. Furthermore, 7 days of rhein pretreatment thoroughly abolished the efflux of dopamine and its metabolite (3,4-dihydroxyphenylacetic acid) and altered the profile of homovanillic acid, another metabolite of dopamine, in the mPFC.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1 mg/kgDuration : 7 daysType of interaction : P.Kinetics & P.DynamicsInteraction with drug : ClozapineDose/Conc.(drug) : 100 mg/kgResult : PositiveRemark : Type of experiment: rat medial prefrontal cortexNote : Pretreatment with rhein for 7 days increased the total blood concentration of clozapine, but significantly reduced the unbound clozapine concentrations in the medial prefrontal cortex (mPFC) by approximately 3-fold. Furthermore, 7 days of rhein pretreatment thoroughly abolished the efflux of dopamine and its metabolite (3,4-dihydroxyphenylacetic acid) and altered the profile of homovanillic acid, another metabolite of dopamine, in the mPFC.
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1 mg/kgDuration : 7 daysType of interaction : P.Kinetics & P.DynamicsInteraction with drug : ClozapineDose/Conc.(drug) : 100 mg/kgResult : PositiveRemark : Type of experiment: rat medial prefrontal cortexNote : Pretreatment with rhein for 7 days increased the total blood concentration of clozapine, but significantly reduced the unbound clozapine concentrations in the medial prefrontal cortex (mPFC) by approximately 3-fold. Furthermore, 7 days of rhein pretreatment thoroughly abolished the efflux of dopamine and its metabolite (3,4-dihydroxyphenylacetic acid) and altered the profile of homovanillic acid, another metabolite of dopamine, in the mPFC.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mg/kgDuration : 7 daysType of interaction : P.Kinetics & P.DynamicsInteraction with drug : ClozapineDose/Conc.(drug) : 100 mg/kgResult : PositiveRemark : Type of experiment: rat medial prefrontal cortexNote : Pretreatment with rhein for 7 days increased the total blood concentration of clozapine, but significantly reduced the unbound clozapine concentrations in the medial prefrontal cortex (mPFC) by approximately 3-fold. Furthermore, 7 days of rhein pretreatment thoroughly abolished the efflux of dopamine and its metabolite (3,4-dihydroxyphenylacetic acid) and altered the profile of homovanillic acid, another metabolite of dopamine, in the mPFC.
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mg/kgDuration : 7 daysType of interaction : P.Kinetics & P.DynamicsInteraction with drug : ClozapineDose/Conc.(drug) : 100 mg/kgResult : PositiveRemark : Type of experiment: rat medial prefrontal cortexNote : Pretreatment with rhein for 7 days increased the total blood concentration of clozapine, but significantly reduced the unbound clozapine concentrations in the medial prefrontal cortex (mPFC) by approximately 3-fold. Furthermore, 7 days of rhein pretreatment thoroughly abolished the efflux of dopamine and its metabolite (3,4-dihydroxyphenylacetic acid) and altered the profile of homovanillic acid, another metabolite of dopamine, in the mPFC.
