ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ผล

Activity : DRUG INTERACTION

Solvent/Active Compound : -

Type of experiment : in vivo

Type of animal : rat

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Oral administration

Dose/Conc.(herb) : 50% unripe plantain (standard pellet diet: unripe plantain, 1:1)

Duration : blood sample were taken before oral administration of pefloxacin an at 0.5, 1.0, 1.5, 2.0, 3.0, 4.0, 6.0, 8.0, 10.0, 12.0 and 24.0 h after administered.

Type of interaction : Pharmacodynamics

Interaction with drug : Pefloxacin

Dose/Conc.(drug) : -

Result : Positive

Remark : Results: the results indicate the relative extent of bioavailability of pefloxacin in the presence of 50% and 100% unripe plantain respectively, was significantly (p<0.05) greater than that of pefloxacin in the presence of standard pellet feeds. This was reflected by a mean increase of 23% and 45% in area under the curve (AUC 0-24) when pefloxacin was given with 50% 100% unripe plantain respectively. It was also noted that the pefloxacin peak plasma concentration was increase by 19% when given with 50% unripe plantain or 30% when given with 100% unripe plantain. There was no significant change in the mean time to reach peak plasma concentration, a rough estimate of absorption rate.

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