Part Used : -
Activity : CYP3A4 INDUCTION
Solvent/Active Compound : hypericin
Type of experiment : human
Type of animal : -
Type of study : Open trial
N(Total) : 13 (M/F=4/9)
N(Treatment) : 13 (M/F=4/9)
Sex : Both sex
Age : 30+/-7.5 yrs. (range 20-41 yrs.)
Route : Oral administration
Dose/Conc.(herb) : one 300-mg tablet of reagent-grade St John's Wort extract standardized to 0.3% hypericin three times a day
Duration : 14 days
Type of interaction : Pharmacokinetics
Interaction with drug : -
Dose/Conc.(drug) : -
Remark : Treatment with St John's Wort for 14 days resulted in significant increases in the urinary 6-Beta-hydroxycortisol/cortisol ratio. This finding suggests that St John's Wort is an inducer of CYP3A4.
Note : Subjects: healthy volunteers.
