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| Thai / English name |
Part Used : น้ำจากผลActivity : CYP3A INHIBITIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : non specifiedN(Total) : 8 (M/F=7/1)N(Treatment) : 8 (M/F=7/1)Sex : Both sexAge : 33+/- yrs. (range 21-45 yrs.)Route : Oral administrationDose/Conc.(herb) : 200 mL grapefruit juice 30 minutes before and again together with their daily dose of methadoneDuration : 5 daysType of interaction : PharmacokineticsInteraction with drug : MethadoneDose/Conc.(drug) : methadone was given once per day and remained constant throughout the study (mean, 107+/-31 mg/d; range, 63-150 mg/d)Result : PositiveRemark : Grapefruit juice significantly reduced CYP3A activity as measured by the midazolam phenotyping test. It led to a modest in Cmax and AUCO-24 and a decrease in the apparent clearance for R-, S-, and R, S-methadone. No sign of overdosage was reported or noted during the study.Note : Subjects: opioid-dependent patients undergoing methadone maintenance treatment. Grapefruit juice intake is not recommended during methadone maintenance treatment, in particular in patients initiating such a treatment.
Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : non specifiedN(Total) : 8 (M/F=7/1)N(Treatment) : 8 (M/F=7/1)Sex : Both sexAge : 33+/- yrs. (range 21-45 yrs.)Route : Oral administrationDose/Conc.(herb) : 200 mL grapefruit juice 30 minutes before and again together with their daily dose of methadoneDuration : 5 daysType of interaction : PharmacokineticsInteraction with drug : MethadoneDose/Conc.(drug) : methadone was given once per day and remained constant throughout the study (mean, 107+/-31 mg/d; range, 63-150 mg/d)Result : PositiveRemark : Grapefruit juice significantly reduced CYP3A activity as measured by the midazolam phenotyping test. It led to a modest in Cmax and AUCO-24 and a decrease in the apparent clearance for R-, S-, and R, S-methadone. No sign of overdosage was reported or noted during the study.Note : Subjects: opioid-dependent patients undergoing methadone maintenance treatment. Grapefruit juice intake is not recommended during methadone maintenance treatment, in particular in patients initiating such a treatment.
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : non specifiedN(Total) : 8 (M/F=7/1)N(Treatment) : 8 (M/F=7/1)Sex : Both sexAge : 33+/- yrs. (range 21-45 yrs.)Route : Oral administrationDose/Conc.(herb) : 200 mL grapefruit juice 30 minutes before and again together with their daily dose of methadoneDuration : 5 daysType of interaction : PharmacokineticsInteraction with drug : MethadoneDose/Conc.(drug) : methadone was given once per day and remained constant throughout the study (mean, 107+/-31 mg/d; range, 63-150 mg/d)Result : PositiveRemark : Grapefruit juice significantly reduced CYP3A activity as measured by the midazolam phenotyping test. It led to a modest in Cmax and AUCO-24 and a decrease in the apparent clearance for R-, S-, and R, S-methadone. No sign of overdosage was reported or noted during the study.Note : Subjects: opioid-dependent patients undergoing methadone maintenance treatment. Grapefruit juice intake is not recommended during methadone maintenance treatment, in particular in patients initiating such a treatment.
