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Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 56 (M/F = 24/32)N(Treatment) : 3Sex : Both sexAge : 68.7 +/- 7.7 yrsRoute : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Aspirin*/Acetylsalicylic acid/ASA/EcosprinDose/Conc.(drug) : -Result : PositiveRemark : เจียวกู่หลานมีฤทธิ์ยับยั้งการเกาะกลุ่มของเกล็ดเลือด จึงเสริมฤทธิ์ของ aspirin เพิ่มความเสี่ยงการเกิดภาวะเลือดออกNote : Data incomplete, data from review article
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Gulanpenisong tablets*Type of experiment : -Type of animal : -Type of study : non specifiedN(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Prednisone*/Deltacortisone/DeltdehydrocortisoneDose/Conc.(drug) : -Result : PositiveRemark : Result: The combination of the saponin can inhibited the toxicity of the glucocorticoid prednisone e.g. atrophy of adrenal and thymus glands and other side effects.Note : *Solvent/compound: Gulanpenisong tablets (double layer or sandwich) or capsules comprise Gynostemma pentaphyllum total saponin and prednisone (1:4-16 or 1:7-9). Data incomplete.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : saponinsType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : saponins administered i.p. at 10 mg/kg/dayDuration : 10 daysType of interaction : PharmacokineticsInteraction with drug : Dexamethasone*/DexamethazoneDose/Conc.(drug) : -Result : -Remark : Result: Side effects of glycocorticoids are prevented by saponins of G. pentaphyllum. Thus, saponins administered i.p. at 10 mg/kg/day for 10 days to rats that had received dexamethasone i.p. at 10 mg/kg/day for 10 days prevented the side effects of dexamethasone, namely, the adrenal and thymus gland constriction.Note : Data incomplete.
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : *Gynostemma pentaphyllum teaType of experiment : -Type of animal : -Type of study : non specifiedN(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : GlucocorticoidDose/Conc.(drug) : -Result : PositiveRemark : Resut: The tea has counteracting the adverse side effects of glucocorticoid.Note : *Solvent/compound: Gynostemma pentaphyllum tea was characterized by heating Gynostemma pentaphyllum leaf to deactivate enzymes at 100 degrees celsius for 3-15 min, with the weight ratio of water and Gynostemma pentaphyllum leaf being (5-10):1. Data incomplete.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : gypenosideType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.1 mg/mLDuration : -Type of interaction : PharmacokineticsInteraction with drug : ColchicineDose/Conc.(drug) : -Result : PositiveRemark : In the presence of total gypenoside preparation (0.1 mg/ml), an approximately 15-fold reversal of colchicine (COL) resistance was observed in P-gp-overexpressed CEM/VLB(100) cells. A purified gypenoside sample (gypenoside fraction 100) exhibited even more significant reversal of COL resistance (approximately 42-fold) in the CEM/VLB(100) cells. Further examination of the reversal effect of fraction 100 in membrane vesicles derived from CEM/VLB(100) cells using the continuous fluorescence method found that gypenoside fraction 100 at 0.1 mg/ml completely abolished the transport of fluorescein-COL.Note : Data incomplete
