CUCURBITACEAE Gynostemma pentaphyllum  (Thunb.) Makino

 Synonym

    none ...
 Thai / English name

  • ปัญจขันธ์*

[1-1] of 1 article(s) found

 หน้า  1  

[1] INHIBITORY EFFECTS OF GYPENOSIDES ON SEVEN HUMAN CYTOCHROME P450 ENZYMES IN VITRO.
MIN HE,JIAN JIANG .,FURONG QIU,ET AL.
FOOD CHEM TOXICOL 2013 Vol.57(),262-5  $45906 [Full]

Part Used : ไม่ระบุ
Activity : CYP2C8 INHIBITION
Solvent/Active Compound : gypenosides
Type of experiment : in vitro
Type of animal : -
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : -
Dose/Conc.(herb) : -
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : -
Dose/Conc.(drug) : -
Result : Positive
Remark : Gypenosides showed the strongest inhibition of CYP2D6, followed by CYP2C8, CYP3A4 and CYP2C9. The IC50 values were 1.61 microgram/mL, 20.06 microgram/mL, 34.76 microgram/mL (CYP3A4/midazolam), 46.73 microgram/mL (CYP3A4/testosterone), 54.52 microgram/mL, respectively.


 หน้า  1