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| Thai / English name |
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 0.3-3.0 g/kgDuration : -Type of interaction : PharmacodynamicsInteraction with drug : MorphineDose/Conc.(drug) : 2-10 mg/kg, SCResult : PositiveRemark : Type of experiment: In acute experiments, mice received subcutaneous (s.c.) morphine (2, 5, or 10 mg/kg, respectively), immediately following oral distilled water or precessed Aconiti tuber (PAT) (0.3, 1.0, or 3.0 g/kg, respectively).Note : PAT at analgesic doses could antagonize acute morphine antinociception in morphine naive mice but potentiate chronic morphine antinociception in morphine-tolerant mice through attenuation of morphine tolerance.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 0.3-3.0 g/kgDuration : 11 daysType of interaction : PharmacodynamicsInteraction with drug : MorphineDose/Conc.(drug) : 10 mg/kg, SCResult : PositiveRemark : Type of experiment: In chronic experiments, mice received s.c. morphine (10 mg/kg) and oral distilled water or processed Aconiti tuber (PAT) (0.3, 1.0 or 3.0 g/kg) once daily for 11 days.Note : PAT at analgesic doses could antagonize acute morphine antinociception in morphine naive mice but potentiate chronic morphine antinociception in morphine-tolerant mice through attenuation of morphine tolerance.
