ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

MENISPERMACEAE Tinospora cordifolia (DC.) Miers

Synonym

none ...

Thai / English name

GUDUCHI*

[1-1] of 1 article(s) found

หน้า 1

[1] BERBERINE IN COMBINATION WITH DOXORUBICIN SUPPRESSES GROWTH OF MURINE MELANOMA B16F10 CELLS IN CULTURE AND XENOGRAFT.
ANIL MITTAL, SABA TABASUM, RANA P. SINGH
PHYTOMEDICINE 2014 Vol.21(),340-7 $50914 [Full]

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : Berberine

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 50 micromolar

Duration : -
Type of interaction : Pharmacodynamics

Interaction with drug : Doxorubicin*/Adrimycin/ADR/Adria
Dose/Conc.(drug) : -

Result : Positive

Remark : Results; Berberine (50 micromolar) and doxorubicin (25 nanomolar) combination strongly inhibited murine melanoma B16F10 cells growth and induced cell death, and caused G2/M arrest in cell cycle together with a decrease in Kip 1/p27. Berberine showed stronger inhibitory effect on ERK1/2 phosphorlation as compared to Akt phosphorylation, whereas the combination of the drugs showed greater inhibitory effect on Akt phosphorylation. Type of experiment: murine melanoma cell line B16F10

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : Berberine

Type of experiment : in vivo
Type of animal : mouse

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 100 mg/kg body weight, daily

Duration : 27 days
Type of interaction : Pharmacodynamics

Interaction with drug : Doxorubicin*/Adrimycin/ADR/Adria
Dose/Conc.(drug) : -

Result : Positive

Remark : Results: combination of berberine (100 mg/kg/day) and doxorubicin (4 mg/kg body weight, once a week on day 1, 8, 15 and 22; total four doses) resulted in a significant and strong decrease in tumor volume (85%, p < 0.005) and tumor weight (78%, p < 0.05) as compared to control. Immunohistochemical analysis of tumor samples showed that drug combination decreased PCNA-positive cells (82%, p < 0.001) and increased cleaved caspase-3 positive cells (3-fold, p < 0.05) indicating inhibition of proliferation and an increase in apoptosis, respectively. Type of experiment: Tumor xenograft in mice

หน้า 1

EN

Web Link ที่เกี่ยวข้อง

ที่อยู่