ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ไม่ระบุ

Activity : P-GLYCOPROTEIN INHIBITION

Solvent/Active Compound : highly oxygenated lanostane derivatives

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : 20 micromolar

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : -

Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: human breast adenocarcinoma cell line (MCF-7) and adriamycin-resistant MCF-7 (MCF-7/ADR) cells

Note : Ganoderlactone A, Ganoderlactone E, 11Beta-hydroxy-3,7-dioxo-5alpha-lanosta-8,24(E)-dien-26-oic acid and methyl lucidenate F had significant inhibitory effects on P-glycoprotein.

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