ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : น้ำมัน

Activity : CYP2C9 INHIBITION

Solvent/Active Compound : cis-linoleic acid

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : 179 micromolar

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : -

Dose/Conc.(drug) :

Result : Positive

Remark : *Part used: น้ำมันจากดอก Results: lC50 values (micromolar) of test compounds for CYP1A2 inhibition = 10.57 micromolar lC50 values (micromolar) of test compounds for CYP2C9 inhibition = 7.72 micromolar lC50 values (micromolar) of test compounds for CYP2C19 inhibition = 35.77 micromolar lC50 values (micromolar) of test compounds for CYP2D6 inhibition = 48.46 micromolar lC50 values (micromolar) of test compounds for CYP3A4 (BFC) inhibition = 18.46 micromolar

Note : Evaluated the effects of 25 purified components of commonly used herbal products on the catalytic activity of cDNA-expressed cytochrome P450 isoforms in in vitro experiments. Increasing concentrations of the compounds were incubated with a panel of recombinant human CYP isoforms (CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4) and their effects on the conversion of specific surrogate substrates measured fluorometrically in a 96-well plate format.

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