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GINKGOACEAE Ginkgo biloba L.

Synonym

none ...

Thai / English name

แปะก๊วย*

[1-2] of 2 article(s) found

หน้า 1 2

[1] BIOACTIVE TERPENOIDS AND FLAVONOIDS FROM GINKGO BILOBA EXTRACT INDUCE THE EXPRESSION OF HEPATIC DRUG-METABOLIZING ENZYMES THROUGH PREGNANE X RECEPTOR, CONSTITUTIVE ANDROSTANE RECEPTOR, AND ARYL HYDROCARBON RECEPTOR-MEDIATED PATHWAYS.
LI L,STANTON JD,TOLSON AH,ET AL.
PHARM RES 2009 Vol.26(4),872-82 $23607 [Full]

Part Used : ใบ
Activity : ARYL HYDROCARBON RECEPTOR ACTIVATION

Solvent/Active Compound : The standardized Ginkgo biloba leaf extract (EGb 761)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : EGb 761 100 mcg/ml

Duration : Transfected cells were then treated with EGb 761 for 24 h.
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Result: EGb 761 and its flavonoids increased the expression of UGT1A1-gtPBREM reporter gene, whereas all the terpenoids tested exhibit no effects on aryl hydrocarbon recepotr (AhR) activity.

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

Part Used : ใบ
Activity : ARYL HYDROCARBON RECEPTOR ACTIVATION

Solvent/Active Compound : quercetin (Que)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Que 25 mcg/ml

Duration : Transfected cells were then treated with Que for 24 h.
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Result: EGb 761 and its flavonoids increased the expression of UGT1A1-gtPBREM reporter gene, whereas all the terpenoids tested exhibit no effects on aryl hydrocarbon recepotr (AhR) activity.

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

Part Used : ใบ
Activity : ARYL HYDROCARBON RECEPTOR ACTIVATION

Solvent/Active Compound : kaempferol (Kae)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Kae 20 mcg/ml

Duration : Transfected cells were then treated with Kae for 24 h.
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Result: EGb 761 and its flavonoids increased the expression of UGT1A1-gtPBREM reporter gene, whereas all the terpenoids tested exhibit no effects on aryl hydrocarbon recepotr (AhR) activity.

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

Part Used : ใบ
Activity : ARYL HYDROCARBON RECEPTOR ACTIVATION

Solvent/Active Compound : tamarixetin (Tam)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Tam 10 mcg/ml

Duration : Transfected cells were then treated with Tam for 24 h.
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Result: EGb 761 and its flavonoids increased the expression of UGT1A1-gtPBREM reporter gene, whereas all the terpenoids tested exhibit no effects on aryl hydrocarbon recepotr (AhR) activity.

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

Part Used : ใบ
Activity : ARYL HYDROCARBON RECEPTOR ACTIVATION

Solvent/Active Compound : ginkgolide A (GA)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : GA 50 microM

Duration : Transfected cells were then treated with GA for 24 h.
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Result: EGb 761 and its flavonoids increased the expression of UGT1A1-gtPBREM reporter gene, whereas all the terpenoids tested exhibit no effects on aryl hydrocarbon recepotr (AhR) activity.

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

Part Used : ใบ
Activity : ARYL HYDROCARBON RECEPTOR ACTIVATION

Solvent/Active Compound : ginkgolide B (GB)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : GB 50 microM

Duration : Transfected cells were then treated with GB for 24 h.
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Result: EGb 761 and its flavonoids increased the expression of UGT1A1-gtPBREM reporter gene, whereas all the terpenoids tested exhibit no effects on aryl hydrocarbon recepotr (AhR) activity.

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

Part Used : ใบ
Activity : ARYL HYDROCARBON RECEPTOR ACTIVATION

Solvent/Active Compound : bilobalide (BB)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : BB 50 microM

Duration : Transfected cells were then treated with BB for 24 h.
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Result: EGb 761 and its flavonoids increased the expression of UGT1A1-gtPBREM reporter gene, whereas all the terpenoids tested exhibit no effects on aryl hydrocarbon recepotr (AhR) activity.

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

[2] MODULATION OF CYP1B1 AND CYP1A1 GENE EXPRESSION AND ACTIVATION OF ARYL HYDROCARBON RECEPTOR BY GINKGO BILOBA EXTRACT IN MCF-10A HUMAN MAMMARY EPITHELIAL CELLS.
RAJARAMAN G,YANG G,CHEN J,ET AL.
CAN J PHYSIOL PHARMACOL 2009 Vol.87(9),674-83 $29218 [Full]

Part Used : ไม่ระบุ
Activity : ARYL HYDROCARBON RECEPTOR ACTIVATION

Solvent/Active Compound : Ginkgo biloba extract*

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Ginkgo biloba extract 25, 50, 100, 200, or 300 mcg/mL

Duration : MCF-10A cells were treated with G. biloba extract once every 24 h for 48 h.
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Result: As analyzed by real-time PCR analysis with gene-specific primers, G. biloba extract did not upregulate AhR gene expression.

Note : Solvent/compound: Ginkgo biloba extract contained 6.2% w/w terpene trilactones, consisting of bilobalide (2.8%), ginkgolide A (1.1%), ginkgolide B (0.3%), ginkgolide C (1.4%), and ginkgolide J (0.6%). It also contained 21% w/w flavonols (as sum of the aglycone and glycosides), consisting of quercetin (10.6%), kaempferol (6.3%), and isorhamnetin (4.1%).

Part Used : ไม่ระบุ
Activity : ARYL HYDROCARBON RECEPTOR ACTIVATION

Solvent/Active Compound : Ginkgo biloba extract*

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Ginkgo biloba extract 25, 50, 100, 200 or 300 mcg/mL

Duration : MCF-10A cells were treated with G. biloba extract and 3',4'-dimethoxyflavone (DMF; an antagonist of AhR) at 1, 5, and 10 mmol/L once every 24 h for 48 h.
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Result: As shown by the dose-response, there was a progressive increase in AhR-dependent reporter activity by the Ginkgo biloba extract over the range of concentrations (25-300 mg/mL) investigated in the CYP1B1 and CYP1A1 gene expression experiments.

Note : Solvent/compound: Ginkgo biloba extract contained 6.2% w/w terpene trilactones, consisting of bilobalide (2.8%), ginkgolide A (1.1%), ginkgolide B (0.3%), ginkgolide C (1.4%), and ginkgolide J (0.6%). It also contained 21% w/w flavonols (as sum of the aglycone and glycosides), consisting of quercetin (10.6%), kaempferol (6.3%), and isorhamnetin (4.1%).

Part Used : ไม่ระบุ
Activity : ARYL HYDROCARBON RECEPTOR ACTIVATION

Solvent/Active Compound : bilobalide

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : bilobalide 2.8 mcg/mL

Duration : MCF-10A cells were treated with bilobalide for 24 h
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Result: None of the terpene trilactones increased CYP1B1 or CYP1A1 mRNA expression. These compounds also and had no effect on AhR dependent report activity.

Note : Solvent/compound: Ginkgo biloba extract contained 6.2% w/w terpene trilactones, consisting of bilobalide (2.8%), ginkgolide A (1.1%), ginkgolide B (0.3%), ginkgolide C (1.4%), and ginkgolide J (0.6%). It also contained 21% w/w flavonols (as sum of the aglycone and glycosides), consisting of quercetin (10.6%), kaempferol (6.3%), and isorhamnetin (4.1%).

หน้า 1 2

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