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Part Used : ใบActivity : PENTOXYRESORUFIN-O-DEALKYLASE(PROD) STIMULATIONSolvent/Active Compound : ginkgo biloba ext. (GBE)Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : GBE (1,000 mg/kg, contg. bilobalide at 42 mg/kg)Duration : 5 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: Treatment with bilobalide induced CYPs markedly and in a dose-dependent manner, and the level of induction was quite similar between bilobalide (42 mg kg-1) and GBE. Treatment with GBE and with bilobalide greatly induced pentoxyresorufin O-dealkylase activity. These findings indicate that bilobalide is the major substance in GBE that induces hepatic CYPs.Note : Data incomplete.
Part Used : ใบActivity : PENTOXYRESORUFIN-O-DEALKYLASE(PROD) STIMULATIONSolvent/Active Compound : bilobalideType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : bilobalide (10.5, 21 and 42 mg/kg)Duration : 5 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: Treatment with bilobalide induced CYPs markedly and in a dose-dependent manner, and the level of induction was quite similar between bilobalide (42 mg kg-1) and GBE. Treatment with GBE and with bilobalide greatly induced pentoxyresorufin O-dealkylase activity. These findings indicate that bilobalide is the major substance in GBE that induces hepatic CYPs.Note : Data incomplete.
