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GINKGOACEAE Ginkgo biloba L.

Synonym

none ...

Thai / English name

แปะก๊วย*

[1-1] of 1 article(s) found

หน้า 1

[1] IDENTIFICATION OF GINKGO BILOBA AS A NOVEL ACTIVATOR OF PREGNANE X RECEPTOR.
YEUNG EYH,SUEYOSHI T,NEGISHI M,ET AL.
DRUG METAB DISPOS 2008 Vol.36(11),2270-6 430151 [Abstract]

Part Used : ไม่ระบุ
Activity : P-GLYCOPROTEIN STIMULATION

Solvent/Active Compound : G. biloba extract

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 200 mg/mL

Duration : 72 h
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : G. biloba ext. at 200, 400m and 800 mg/mL increased CYP3A4 mRNA expression by 1.7-, 2.4-, and 2.5-fold, resp. The same concentration of the ext. increased CYP3A5 (1.3-3.6-fold) and P- glycoprotein (ABCB) 1 (2.7-6.4-fold) mRNA expression. L-sulforaphane (an hPXR antagonist) decreased CYP3A4, CYP3A5, and ABCB1 gene expression in cells treated with G. biloba ext.

Note : Data incomplete

Part Used : ไม่ระบุ
Activity : P-GLYCOPROTEIN STIMULATION

Solvent/Active Compound : G. biloba extract

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 400 mg/mL

Duration : 72 h
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : G. biloba ext. at 200, 400m and 800 mg/mL increased CYP3A4 mRNA expression by 1.7-, 2.4-, and 2.5-fold, resp. The same concentration of the ext. increased CYP3A5 (1.3-3.6-fold) and P- glycoprotein (ABCB) 1 (2.7-6.4-fold) mRNA expression. L-sulforaphane (an hPXR antagonist) decreased CYP3A4, CYP3A5, and ABCB1 gene expression in cells treated with G. biloba ext.

Note : Data incomplete

Part Used : ไม่ระบุ
Activity : P-GLYCOPROTEIN STIMULATION

Solvent/Active Compound : G. biloba extract

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 800 mg/mL

Duration : 72 h
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : G. biloba ext. at 200, 400m and 800 mg/mL increased CYP3A4 mRNA expression by 1.7-, 2.4-, and 2.5-fold, resp. The same concentration of the ext. increased CYP3A5 (1.3-3.6-fold) and P- glycoprotein (ABCB) 1 (2.7-6.4-fold) mRNA expression. L-sulforaphane (an hPXR antagonist) decreased CYP3A4, CYP3A5, and ABCB1 gene expression in cells treated with G. biloba ext.

Note : Data incomplete

หน้า 1

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