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GINKGOACEAE Ginkgo biloba L.

Synonym

none ...

Thai / English name

แปะก๊วย*

[1-2] of 2 article(s) found

หน้า 1

[1] STUDIES ON INTERACTIONS BETWEEN FUNCTIONAL FOODS OR DIETARY SUPPLEMENTS AND MEDICINES. IV. EFFECTS OF GINKGO BILOBA LEAF EXTRACT ON THE PHARMACOKINETICS AND PHARMACODYNAMICS OF NIFEDIPINE IN HEALTHY VOLUNTEERS.
YOSHIOKA M,OHNISHI N,KOISHI T,ET AL.
BIOL PHARM BULL 2004 Vol.27(12),2006-9 $12987 [Full]

Part Used : ใบ
Activity : CARDIOVASCULAR EFFECTS(UNSPECIFIED)

Solvent/Active Compound : -

Type of experiment : human
Type of animal : -

Type of study : Cross over

N(Total) : 8 (M/F=8/-)
N(Treatment) : 8 (M/F=8/-)

Sex : Male
Age : 24-45 (29+/-3 years)

Route : Oral administration
Dose/Conc.(herb) : two capsules containing Ginkgo biloba leaf extract (GBE) (a total GBE dose of 240 mg: general daily dose in human)

Duration : 2 weeks
Type of interaction : Pharmacodynamics

Interaction with drug : Nifedipine
Dose/Conc.(drug) : 10 mg

Result : Positive

Remark : 2 subjects were approximately doubled by GBE, and they had severer and longer-lasting headaches with GBE than without GBE, with dizziness or hot flushes in combination with GBE. The mean heart rate after oral administration of NFP with GBE tended to be faster than that without GBE at every time point.

Note : Subjects : Healthy volunteers Accordingly, it was concluded that GBE and NEP should not be simultaneously ingested as much as possible, and careful monitoring is needed when administering NEP concomitantly with GBE to humans.

[2] THE EFFECT OF MECLOFENOXATE WITH GINKGO BILOBA EXTRACT OR ZINC ON LIPID PEROXIDE, SOME FREE RADICAL SCAVENGERS AND THE CARDIOVASCULAR SYSTEM OF AGED RATS.
AL-ZUHAIR H,EL-FATTAH AAA,EL-SAYED MI
PHARMACOL RES 1998 Vol.38(1),65-72 293265 [Abstract]

Part Used : ไม่ระบุ
Activity : CARDIOVASCULAR EFFECTS(UNSPECIFIED)

Solvent/Active Compound : extract of ginkgo biloba (EGb-761)

Type of experiment : -
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 150 mg/kg

Duration : 4 weeks
Type of interaction : P.Kinetics & P.Dynamics

Interaction with drug : Meclofenoxate*/Clophenoxate/Meclophenoxate/Centrophenoxine
Dose/Conc.(drug) : 100 mg/kg daily

Result : Positive

Remark : Type of experiment: Aged rats were treated with meclofenoxate (MF) alone or with either EGb or Zn for 4 wk. Results: Treatment of aged rats with MF alone or combined with either EGb or Zn caused improvement in the measured free radical scavengers esp. in brain and heart. Both EGb and Zn induced a potential effect of MF action on blood pressure and heart rate.

Note : Data incomplete

หน้า 1

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