Remark : Type of experiment: human liver microsomes
Results: Weak or negligible inhibitory activity was found for the terpene trilactones (ginkgolides A, B, C and J, and bilobalide), and the flavonol glycosides. However 50% inhibitory activity (IC50) was found at concns. less than 10 microgram/ml for the flavonol aglycons (kaempferol, quercetin, apigenin, myricetin, tamarixetin) with CYP1A2 and CYP3A. Quercetin, the biflavone amentoflavone, sesamin, as well as (Z,Z)-4,4'-(1,4-pentadiene-1,5-diyl) diphenol and 3-nonadec-8-enylbenzene-1,2-diol, were also inhibitors of CYP2C9.