ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ใบ

Activity : CYTOCHROME P-450 BINDING

Solvent/Active Compound : Ginkgo biloba leaf ext. (GBE)

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : Effect of GBE on PAF (25, 50 , 100, 200 and 1,000 micrograms/L-1) induced platelet aggregation was estimated by preincubation cryopreserved human primary hepatocytes (HPHs) with GBE before the addition of PAF.

Duration : -

Type of interaction : Pharmacodynamics

Interaction with drug : -

Dose/Conc.(drug) : Platelet activating factor (PAF) 25, 50, 100, 200 and 1,000 micrograms/L-1.

Result : Positive

Remark :

Note : Result: GBE showed the inhibition of PAF-induced platelet aggregation with IC50 of 33 mg/L-1, 30% enhancement over the control. These effects of GBE were reduced significantly by selectively inhibiting CYP1A2 but CYP2B6, 2C19, 2E1 and 3A4. The inhibitive effects of GBE on PAF induced platelet aggregation are regulated by CYP1A2. Data incomplete.

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