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Part Used : -Activity : CYP2B1/2 INDUCTIONSolvent/Active Compound : The standard Ginkgo biloba extraction (EGB761)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : EGB761 10 mg/kg/dayDuration : 10 daysType of interaction : PharmacokineticsInteraction with drug : Propranolol*/Propanolol/Beta-propranololDose/Conc.(drug) : -Result : PositiveRemark :Note : - A single oral dose of propranolol (10 mg/kg) was administered on day 11. - Data incomplete
Part Used : -Activity : CYP2B1/2 INDUCTIONSolvent/Active Compound : The standard Ginkgo biloba extraction (EGB761)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : EGB761 100 mg/kg/dayDuration : 10 daysType of interaction : PharmacokineticsInteraction with drug : Propranolol*/Propanolol/Beta-propranololDose/Conc.(drug) : -Result : PositiveRemark : Pretreatment of EGB761 at 100 mg/kg for 10 days significantly reduced the area uder the plasma concentration time curve (AUC) and maximum plasma concentration (Cmax) of propranolol, whereas those values of N-desisopropylpropranolol (NDP) were significantly increased.Note : - A single oral dose of propranolol (10 mg/kg) was administered on day 11. - Data incomplete
Part Used : ไม่ระบุActivity : CYP2B1/2 INDUCTIONSolvent/Active Compound : BilobalideType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Bilobalide significantly induced the activity, protein, and mRNA expression of CYP3A1 and 1A2, and increased CYP 2E1 activity and CYP2B1/2 protein expression in a dose-dependent manner.Note : Data incomplete
